Geoffrey A. Wood
Assistant Co-Director, Institute for Comparative Cancer Investigation | Professor
DVM, PhD, DVSc (pathology)
gewood@uoguelph.ca
Office: PAHL 3823
519-824-4120 Ext. 54632
Lab: PAHL 3808
519-824-4120 Ext. 53616
Research Interests
- Pathology of neoplasia
- Multi-species comparative cancer genetics
- Biomarkers of cancer in dogs
- Mouse models of human cancer
Current Graduate Students
- Morla Phan - PhD
- Dante Meza Ruiz - DVSc
- Heather Treleaven - PhD
- Rachael Speare - DVSc
- Thompson Worden - MSc
Selected Publications
1. Moreira S, Polena E, Gordon V, Abdulla S, Mahendram S, Cao J, et al. A Single TCF Transcription Factor, Regardless of Its Activation Capacity, Is Sufficient for Effective Trilineage Differentiation of ESCs. Cell Rep. 2017 Sep;20(10):2424–38.
2. Mould RC, AuYeung AWK, van Vloten JP, Susta L, Mutsaers AJ, Petrik JJ, et al. Enhancing Immune Responses to Cancer Vaccines Using Multi-Site Injections. Sci Rep. 2017 Aug;7(1):8322.
3. Santry LA, Ingrao JC, Yu DL, de Jong JG, van Lieshout LP, Wood GA, et al. AAV vector distribution in the mouse respiratory tract following four different methods of administration. BMC Biotechnol. 2017 May;17(1):43.
4. Calvalido J, Wood GA, Mutsaers AJ, Wood D, Sears W, Woods JP. Comparison of serum cytokine levels between dogs with multicentric lymphoma and healthy dogs. Vet Immunol Immunopathol. 2016 Dec;182:106–14.
5. Power KA, Lu JT, Monk JM, Lepp D, Wu W, Zhang C, et al. Purified rutin and rutin-rich asparagus attenuates disease severity and tissue damage following dextran sodium sulfate-induced colitis. Mol Nutr Food Res. 2016 Nov;60(11):2396–412.
6. Crozier C, Wood GA, Foster RA, Stasi S, Liu JHW, Bartlett JMS, et al. KRAS Mutations in Canine and Feline Pancreatic Acinar Cell Carcinoma. J Comp Pathol. 2016 Jul;155(1):24–8.
7. Monk JM, Lepp D, Zhang CP, Wu W, Zarepoor L, Lu JT, et al. Diets enriched with cranberry beans alter the microbiota and mitigate colitis severity and associated inflammation. J Nutr Biochem. 2016 Feb;28:129–39.
8. Thompson JJ, Morrison JA, Pearl DL, Boston SE, Wood GA, Foster RA, et al. Receptor Tyrosine Kinase Expression Profiles in Canine Cutaneous and Subcutaneous Mast Cell Tumors. Vet Pathol. 2016 May;53(3):545–58.
9. van der Weyden L, Patton EE, Wood GA, Foote AK, Brenn T, Arends MJ, et al. Cross-species models of human melanoma. J Pathol. 2016 Jan;238(2):152–65.
10. Monk JM, Zhang CP, Wu W, Zarepoor L, Lu JT, Liu R, et al. White and dark kidney beans reduce colonic mucosal damage and inflammation in response to dextran sodium sulfate. J Nutr Biochem. 2015 Jul;26(7):752–60.
11. De Long NE, Barry EJ, Pinelli C, Wood GA, Hardy DB, Morrison KM, et al. Antenatal exposure to the selective serotonin reuptake inhibitor fluoxetine leads to postnatal metabolic and endocrine changes associated with type 2 diabetes in Wistar rats. Toxicol Appl Pharmacol. 2015 May;285(1):32–40.
12. Floras ANK, Holowaychuk MK, Bienzle D, Bersenas AME, Sharif S, Harvey T, et al. N-terminal pro-C-natriuretic peptide and cytokine kinetics in dogs with endotoxemia. J Vet Intern Med. 2014;28(5):1447–53.
13. Dang LTH, Feric NT, Laschinger C, Chang WY, Zhang B, Wood GA, et al. Inhibition of apoptosis in human induced pluripotent stem cells during expansion in a defined culture using angiopoietin-1 derived peptide QHREDGS. Biomaterials. 2014 Sep;35(27):7786–99.
14. Zarepoor L, Lu JT, Zhang C, Wu W, Lepp D, Robinson L, et al. Dietary flaxseed intake exacerbates acute colonic mucosal injury and inflammation induced by dextran sodium sulfate. Am J Physiol Gastrointest Liver Physiol. 2014 Jun;306(12):G1042-55.
15. Zhang C, Monk JM, Lu JT, Zarepoor L, Wu W, Liu R, et al. Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis. Br J Nutr. 2014 May;111(9):1549–63.
16. Chaudhary R, Pierre CC, Nanan K, Wojtal D, Morone S, Pinelli C, et al. The POZ-ZF transcription factor Kaiso (ZBTB33) induces inflammation and progenitor cell differentiation in the murine intestine. PLoS One. 2013;8(9):e74160.
17. MacLennan MB, Clarke SE, Perez K, Wood GA, Muller WJ, Kang JX, et al. Mammary tumor development is directly inhibited by lifelong n-3 polyunsaturated fatty acids. J Nutr Biochem. 2013 Jan;24(1):388–95.
18. Dengler J, Song H, Thavandiran N, Masse S, Wood GA, Nanthakumar K, et al. Engineered heart tissue enables study of residual undifferentiated embryonic stem cell activity in a cardiac environment. Biotechnol Bioeng. 2011 Mar;108(3):704–19.
19. Tan KP, Wood GA, Yang M, Ito S. Participation of nuclear factor (erythroid 2-related), factor 2 in ameliorating lithocholic acid-induced cholestatic liver injury in mice. Br J Pharmacol. 2010 Nov;161(5):1111–21.
20. Molyneux SD, Di Grappa MA, Beristain AG, McKee TD, Wai DH, Paderova J, et al. Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice. J Clin Invest. 2010 Sep;120(9):3310–25.
21. Adissu HA, Hayes G, Wood GA, Caswell JL. Cardiac myxosarcoma with adrenal adenoma and pituitary hyperplasia resembling Carney complex in a dog. Vet Pathol. 2010 Mar;47(2):354–7.
22. Klinger S, Turgeon B, Levesque K, Wood GA, Aagaard-Tillery KM, Meloche S. Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality. Proc Natl Acad Sci U S A. 2009 Sep;106(39):16710–5.
23. Jones RA, Campbell CI, Wood GA, Petrik JJ, Moorehead RA. Reversibility and recurrence of IGF-IR-induced mammary tumors. Oncogene. 2009 May;28(21):2152–62.
24. Hao Z, Duncan GS, Seagal J, Su Y-W, Hong C, Haight J, et al. Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis. Immunity. 2008 Oct;29(4):615–27.
25. Peerani R, Rao BM, Bauwens C, Yin T, Wood GA, Nagy A, et al. Niche-mediated control of human embryonic stem cell self-renewal and differentiation. EMBO J. 2007 Nov;26(22):4744–55.
26. Doble BW, Patel S, Wood GA, Kockeritz LK, Woodgett JR. Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines. Dev Cell. 2007 Jun;12(6):957–71.
27. Clapcote SJ, Lazar NL, Bechard AR, Wood GA, Roder JC. NIH Swiss and Black Swiss mice have retinal degeneration and performance deficits in cognitive tests. Comp Med. 2005 Aug;55(4):310–6.
28. Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JEI, et al. A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development. 2005 Oct;132(19):4375–86.
29. Wood GA, Flenniken A, Osborne L, Fleming C, Vukobradovic I, Morikawa L, et al. Two mouse mutations mapped to chromosome 11 with differing morphologies but similar progressive inflammatory alopecia. Exp Dermatol. 2005 May;14(5):373–9.
30. De Miglio MR, Pascale RM, Simile MM, Muroni MR, Virdis P, Kwong KM-T, et al. Polygenic control of hepatocarcinogenesis in Copenhagen x F344 rats. Int J cancer. 2004 Aug;111(1):9–16.
31. Wood GA, Korkola JE, Archer MC. Tissue-specific resistance to cancer development in the rat: phenotypes of tumor-modifier genes. Carcinogenesis. 2002 Jan;23(1):1–9.
32. Wood GA, Sarma DS, Archer MC. Inheritance of resistance to promotion of preneoplastic liver lesions in Copenhagen rats. Exp Biol Med (Maywood). 2001 Oct;226(9):831–5.
33. Wood GA, Archer MC. Matrix metalloproteinases-2 and 9 do not play a role in the growth of preneoplastic liver lesions in F344 rats. Exp Biol Med (Maywood). 2001 Sep;226(8):799–803.
34. Wood GA, Korkola JE, Archer MC. Resistance of Copenhagen rats to hepatocarcinogenesis does not involve T-cell immunity. Carcinogenesis. 2001 Feb;22(2):357–9.
35. Korkola JE, Wood GA, Archer MC. Cyclin D1 expression during rat mammary tumor development and its potential role in the resistance of the Copenhagen rat. Breast Cancer Res. 1999;1(1):88–94.
36. Ghoshal AK, Xu Z, Wood GA, Archer MC. Induction of hepatic insulin-like growth factor binding protein-1 (IGFBP-1) in rats by dietary n-6 polyunsaturated fatty acids. Proc Soc Exp Biol Med. 2000 Nov;225(2):128–35.
37. Wood GA, Sarma DS, Archer MC. Resistance to the promotion of glutathione S-transferase 7-7-positive liver lesions in Copenhagen rats. Carcinogenesis. 1999 Jul;20(7):1169–75.
38. Wood GA, Korkola JE, Lee VM, Sarma DS, Archer MC. Resistance of Copenhagen rats to chemical induction of glutathione S-transferase 7-7-positive liver foci. Carcinogenesis. 1997 Sep;18(9):1745–50.
39. Korkola JE, Wood GA, Archer MC. Resistance to chemically-induced mammary tumors in Copenhagen X nude-derived F2 athymic rats: evidence that T-cell immunity is not involved in Copenhagen resistance. Carcinogenesis. 1997 Jan;18(1):53–7.
40. Huang IN, Wood GA. Effects of a Mere-Presence Conspecific on Extinction of an Operant. J Gen Psychol. 1984 Jan;110(1):3–9.
41. Yan J, Ojo D, Kapoor A, Lin X, Pinthus JH, Aziz T, et al. Neural cell adhesion protein CNTN1 promotes the metastatic progression of prostate cancer. Cancer Res. 2016;76(6):1603–14.
42. Adissu HA, McKerlie C, Di Grappa M, Waterhouse P, Xu Q, Fang H, et al. Timp3 loss accelerates tumour invasion and increases prostate inflammation in a mouse model of prostate cancer. Prostate [Internet]. 2015 Dec [cited 2017 Feb 16];75(16):1831–43. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26332574
43. Wong N, Gu Y, Kapoor A, Lin X, Ojo D, Wei F, et al. Upregulation of FAM84B during prostate cancer progression. Oncotarget [Internet]. 2017 Feb 7 [cited 2017 Feb 16]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/28186973
44. Jackson HW, Hojilla C V, Weiss A, Sanchez OH, Wood GA, Khokha R. Timp3 deficient mice show resistance to developing breast cancer. PLoS One. 2015;10(3):1–14.
45. Wood GA, Fata JE, Watson KL, Khokha R. Circulating hormones and estrous stage predict cellular and stromal remodeling in murine uterus. Reproduction [Internet]. 2007/07/10. 2007;133(5):1035–44. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17616732
46. Kelly KF, Ng DY, Jayakumaran G, Wood GA, Koide H, Doble BW. beta-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism. Cell Stem Cell [Internet]. 2011/02/08. 2011;8(2):214–27. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21295277
47. Moorehead R a, Hojilla C V, De Belle I, Wood G a, Fata JE, Adamson ED, et al. Insulin-like growth factor-II regulates PTEN expression in the mammary gland. J Biol Chem [Internet]. 2003;278(50):50422–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/14517213
48. Liu L, Wood G a, Morikawa L, Ayearst R, Fleming C, McKerlie C. Restoration of fertility by orthotopic transplantation of frozen adult mouse ovaries. Hum Reprod [Internet]. 2008;23(1):122–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17993475
49. Hariri M, Wood G a, DiGrappa M a, MacPherson M, Backman S a, Yaffe MJ, et al. Experimental manipulation of radiographic density in mouse mammary gland. Breast Cancer Res [Internet]. 2004;6(5):R540-5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15318935
50. Fyles A, Wood G, Li M, Manoukian AS, Gowing K, Khokha R, et al. Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten +/− mice. Clin Cancer Res. 2008;108:395–401.
51. Hojilla C V, Wood G a, Khokha R. Inflammation and breast cancer: metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer. Breast Cancer Res [Internet]. 2008;10(2):205. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18394187
Search PubMed for additional publications by Dr. Wood.
