Pavneesh Madan

Pavneesh Madan


BVSc&AH, MVSc Hisar, PhD UBC
 Office: Biomed 3605
 519-824-4120 Ext. 54480

 Lab: Biomed 3638
 519-824-4120 Ext. 58261


Research Interests

  • Cellular, molecular and genetic mechanisms regulating preimplantation embryogenesis.
  • Factors affecting early embryo arrest, mortality and survival in embryos produced by reproductive biotechnologies.
  • Epigenetic and signal transduction pathways in controlling early embryo development.
  • Metabolomic and proteomic assessment of embryonic health.

Current Graduate Students

  • Nicole Prudenciano - MBS
  • Esra Ozcan - MBS


Selected Publications


  • Kayla Perkel and Pavneesh Madan. Using proton nuclear magnetic resonance to non-invasively assess bovine embryo viability in vitro. Zygote 2017 Dec; 25(6): 662-674.
  • Rho N, Ashkar FA, Revay T, Madan P, Dufort I, Robert C, Favetta LA, Schmidt C, King WA. THR de novo transcription is essential for early bovine embryo development" which you submitted to Reproduction. Reprod Fertil Dev. 2017 Nov 28. doi: 10.1071/RD17165.
  • Kayla J. Perkel, Allison Tscherner, Casandra Merrill, Jonathan Lamarre and Pavneesh Madan. The ART of selecting the best embryo: A review of early embryonic mortality and bovine embryo viability assessment methods. Mol. Reprod. Dev. 2015 Jul 17. doi: 10.1002/mrd.22525.
  • Ashkar FA, Revay T, Rho N, Madan P, Dufort I, Robert C, Favetta LA, Schmidt C, King WA. Thyroid hormones alter the transcriptome of in vitro-produced bovine blastocysts. Zygote. 2016 Aprl 24(2): 266-76.
  • Bergeron LH, Nykamp SG, Brisson BA, Madan P, Sears W, Gartley CJ. Vaginal impedometry for detection of optimal breeding time in bitches. J Am Vet Med Assoc. 2014 Dec 15;245(12):1360-6. doi: 10.2460/javma.245.12.1360.
  • Betts D. H., Bain N. T., & Madan Pavneesh (2014). The p66Shc Adaptor Protein Controls Oxidative Stress Response in Early Bovine Embryos. PLoS ONE, 9 (1), e86978.
  • Bergeron L. H., Nykamp S. G., Brisson B. A., Madan Pavneesh, & Gartley C. J. (2013). An evaluation of B-mode and color Doppler ultrasonography for detecting periovulatory events in the bitch. Theriogenology, 79 (2), 274-283. 
  • Saini M, Selokar NL, Revey T, Singla SK, Chauhan MS, Palta P, Madan P. Trichostatin A alters the expression of cell cycle controlling genes and microRNAs in donor cells and subsequently improves the yield and quality of cloned bovine embryos in vitro. Theriogenology. 2014 Oct 15;82(7):1036-42.
  • Selokar N, Liz St. John, Tamas Revay, W Allan King, Singla S and Pavneesh Madan. Effect of histone deacetylase inhibitor valproic acid (VPA) treatment on donor cell growth characteristics, cell cycle arrest, apoptosis and handmade cloned bovine embryo production efficiency. Cell Reprogram 2013 Nov 1. [Epub ahead of print].
  • Nathan T Bain, Pavneesh Madan, Dean H Betts. Elevated p66Shc is associated with intracellular redox imbalance in developmentally compromised bovine embryos. Mol Reprod Dev 2013 Jan; 80(1): 22-34.
  • Lindsay H. Bergeron, Stephanie G. Nykamp, Brigitte A. Brisson, Pavneesh Madan and Cathy J. Gartley. An evaluation of the efficacy of color Doppler ultrasonography of canine ovaries for detecting the preovulatory LH peak. Theriogenology 2013 Jan 15;79(2):274-83.
  • Mao Li, Matthilakath M. Vijayan, W. Allan King, John F. Leatherland and Pavneesh Madan (2012). Glucocorticoid receptor activation following elevated oocyte cortisol content is associated with zygote activation, early embryo cell division, and IGF system gene responses in rainbow trout. J Endocrinol2012 Oct;215(1):137-49.
  • Selokar N, Saini M, Muzaffer M, Krishnakanth G, Saha A, Chauhan M, Manik R, Palta P, Madan Pavneesh and Singla S. Roscovitine treatment improves synchronization of donor cell cycle in G0/G1 stage and invitro development of handmade cloned buffalo (Bubalus bubalis) embryos. Cell Reprogram2012 Apr;14(2):146-54.
  • Lindsay H. Bergenon, Stephanie G. Nykamp, Brigitte A. Brisson, Pavneesh Madan and Cathy J. Gartley. An evaluation of the efficacy of color Doppler ultrasonography of canine ovaries for detecting the preovulatory LH peak. Theriogenology  (Revision MSID:THERIO-D-11-00793R1). 
  • Pavneesh Madan. Arrest or survive: a decision of the early preimplantation embryo that influences fertility. In: Moo-Young M, (ed.) Comprehensive Biotechnology, Second Edition 2011, vol. 4, pp. 469-476.
  • Nathan T Bain, Pavneesh Madan, Dean H Betts. The early embryo response to intracellular reactive oxygen species is developmentally regulated. Reprod Fertil Dev 2011 May; 23(4): 561-75.
  • Blondin P, Beaulieu M, Fournier V, Morin N, Crawford L, Pavneesh Madan, King WA. Analysis of bovine sexed sperm for IVF from sorting to the embryo. Theriogenology 2009 Jan 1; 71 (1):30-8.
  • Dean H. Betts and Pavneesh Madan. Permanent Embryo Arrest: Current Concept and Molecular Mechanism. Molecular Human Reproduction 2008 Aug;14 (8):445-53.