Intranet

Craig Bailey

Craig Bailey

Associate Professor

BScH, PhD Queen's

 baileyc@uoguelph.ca
 Office: Biomed 2602
 519-824-4120 Ext. 54954

 Lab: Biomed 2601, 2603
 519-824-4120 Ext. 542644

 

Research Interests

Our research laboratory is broadly interested in both normal and aberrant brain development, and our long-term goal is to identify novel therapeutic strategies to mitigate the impact of specific developmental brain disorders. Current research is focused on the prefrontal cortex and hippocampus, two regions of the brain that are responsible for higher-order cognitive processes including learning, memory and attention. Alterations to the prefrontal cortex and hippocampus are observed in a number of neurodevelopmental disorders such as Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorders (ASD), and also following developmental exposure to drugs such as nicotine and alcohol. Work in our laboratory employs an integrative experimental approach utilizing modern molecular, electrophysiological and behavioural techniques to identify mechanisms underlying the development and function of the prefrontal cortex and hippocampus, and to understand how these processes may be altered within specific developmental brain disorders.

Current Graduate Students

  • Ashley Geremla - PhD
  • Mohammad Hossein Kazazi - MBS
  • Donia Zeng

 

Selected Publications

  • Chung BYT, Bailey CDC (2018) Sex differences in the nicotinic excitation of principal neurons within the developing hippocampal formation. Developmental Neurobiology, in press, DOI: 10.1002/dneu.22646.
  • Chung BYT, Bailey CDC (2018) Similar nicotinic excitability responses across the developing hippocampal formation are regulated by small conductance calcium-activated potassium channels. Journal of Neurophysiology, 119: 1707-1722.
  • Louth EL, Luctkar HD, Heney KA, Bailey CDC (2018) Developmental ethanol exposure alters the morphology of mouse prefrontal neurons in a layer-specific manner. Brain Research, 1678: 94-105. 
  • Louth EL, Sutton CD, Mendell AL, MacLusky NJ, Bailey CDC (2017) Imaging neurons in thick brain slices using the Golgi-Cox method. Journal of Visualized Experiments (JoVE), 122, e55358.
  • Mendell, AL, Atwi S, Bailey CDC, McCloskey D, Scharfman H, MacLusky NJ (2017) Expansion of mossy fibers and CA3 apical dendritic length accompanies spine loss after gonadectomy in male, but not female, rats. Brain Structure & Function, 222: 587-601.
  • Cloke JM, Nguyen R, Chung BYT, Wasserman DI, De Lisio S, Kim JC, Bailey CDC, Winters BD (2016) A novel multisensory integration task reveals robust deficits in rodent models of schizophrenia: converging evidence for remediation via nicotinic receptor stimulation of inhibitory transmission in the prefrontal cortex. The Journal of Neuroscience, 36(50): 12570-12585.
  • Louth EL, Bignell W, Taylor CL, Bailey CDC (2016) Developmental ethanol exposure leads to long-term deficits in attention and its underlying prefrontal circuitry. eNeuro, 3(5) ENEURO.0267-16.2016.
  • Chung BYT, Bignell W, Jacklin DL, Winters BD, Bailey CDC (2016) Postsynaptic nicotinic acetylcholine receptors facilitate excitation of developing CA1 pyramidal neurons. Journal of Neurophysiology, 116: 2043-2055.
  • Phan A, Suchkov S, Molinaro L, Reynolds K, Lymer JM, Bailey CDC, Kow L-M, MacLusky NJ, Pfaff DW, Choleris E (2015) Rapid increases in immature synapses parallel estrogen-induced hippocampal learning enhancements. Proceedings of the National Academy of Sciences (PNAS), 112(52): 16018-16023.
  • Bailey CDC, Alves NC, Nashmi R, De Biasi M, Lambe EK (2012) Nicotinic a5 subunits drive developmental changes in the activation and morphology of prefrontal cortex layer VI neurons. Biological Psychiatry, 71(2): 120-128.
  • Bailey CDC, De Biasi M, Fletcher PJ, Lambe EK (2010) The nicotinic acetylcholine receptor a5 subunit plays a key role in attention circuitry and accuracy. The Journal of Neuroscience, 30(27): 9241-9252.
  • Bailey CDC, Brien JF, Reynolds JN (2001) Chronic prenatal ethanol exposure increases GABA(A) receptor subunit protein expression in the adult guinea pig cerebral cortex. The Journal of Neuroscience, 21(12): 4381-4389.