• Office
  • Biomed 2610
  • 54239
  • Lab:
  • Biomed 2608
  • 54955

Jibran Khokhar

Assistant Professor   |   B.Sc. (Queen's), Ph.D (Toronto)

Research Interests

  • Neurobiology of co-occurring schizophrenia and substance use disorders
  • Combining pharmacological, behavioural and pre-clinical neuroimaging methods to develop novel medications for use in "dual-disorder" patients
  • Uncovering the long-term effects of adolescent drug use, and how these effects might contribute to the risk for serious mental illness and addiction
  • Assessing the neurobiological effects of pesticide contamination in drugs of abuse (e.g., cannabis)

Links

www.khokharlab.com

Selected Publications

  • Green A. I. and Khokhar, J. Y. 2017. Addiction and Schizophrenia: A Translational Perspective. Schizophrenia Res. http://doi.org/10.1016/j.schres.2017.10.008
  • Whitfield-Gabrieli, S., Fischer, A. S., Henricks, A. M., Khokhar, J. Y., Roth, R. M., Brunette, M. F., Green, A. I.,  Understanding marijuana’s effects on functional connectivity of the default mode network in patients with schizophrenia and co-occurring cannabis use disorder: A Pilot Investigation. Schizophrenia Res. http://doi.org/10.1016/j.schres.2017.07.029
  • Khokhar, J. Y., Dwiel, L., Henricks, A., Doucette, W. T., Green, A. I. 2017.  The Link Between Schizophrenia and Substance Use Disorder: A Unifying Hypothesis. Schizophrenia Res. http://doi.org/10.1016/j.schres.2017.04.016
  • Khokhar, J. Y. and Todd, T. P. 2017. Behavioral Predictors of Alcohol Drinking in a Neurodevelopmental Rat Model of Schizophrenia and Co-occurring Alcohol Use Disorder. Schizophrenia Res. http://dx.doi.org/10.1016/j.schres.2017.02.029
  • Khokhar, J. Y., Green, A. I. 2016. Effects of iloperidone, combined with desipramine, on alcohol drinking in the Syrian golden hamster. Neuropharmacology. Jun;105:25-34
  • Doucette, W., Khokhar, J. Y., Green, A. I. 2015. Nucleus Accumbens deep brain stimulation in a rat model of binge eating. Transl. Psychiatry. 5, e695; doi:10.1038/tp.2015.197
  • Chau, D. T.*, Khokhar, J. Y.*, Gulick, D., Dawson, R., Green, A. I. 2015. Desipramine enhances the ability of paliperidone to reduce alcohol drinking. J. Psych. Res. Oct; 69: 9–18.
  • Khokhar, J. Y.*, Chau, D. T.*, Dawson, R., Green, A. I. 2015. Clozapine reconstructed: Haloperidol’s ability to reduce alcohol Intake In the Syrian golden hamster can be enhanced through noradrenergic modulation by desipramine and idazoxan. Drug Alcohol Depen. July; 152:277–281
  • Gulick, D.*, Chau, D. T.*, Khokhar, J. Y.*, Dawson, R., Green, A. I. 2014. Desipramine enhances the ability of risperidone to decrease alcohol intake in the Syrian golden hamster. Psych. Res. Aug 30;218(3):329-34.
  • Khokhar, J. Y. and Tyndale, R. F. 2014. Intracerebroventricularly and Systemically Delivered Inhibitor of Brain Cyp2b (C8-Xanthate), Even Following Chlorpyrifos Exposure, Reduces Chlorpyrifos Activation and Toxicity in Male Rats. Toxicol. Sci. Jul;140(1):49-60.
  • Chau, D.T., Khokhar, J. Y., Dawson, R., Ahmed, J., Xie, H., Green, A. I., 2013. The comparative effects of clozapine versus haloperidol on initiation and maintenance of alcohol drinking in male alcohol-preferring P rat. Alcohol. Dec;47(8):611-8.
  • Zhou, K., Khokhar, J. Y., Bin, Z., and Tyndale, R. F. 2013. First demonstration that CYP2D-mediated opiate metabolic activation alters analgesia in vivo. Biochem Pharmacol.15;85(12): 1848-55.
  • Khokhar, J. Y. and Tyndale, R. F. 2012. Rat Brain Cyp2b-Enzymatic Activation Of Chlorpyrifos To The Oxon Mediates Cholinergic Neurotoxicity.  Toxicol. Sci. 126(2):325-35. 
  • Khokhar, J.Y. and Tyndale, R.F 2011. Drug metabolism within the brain changes drug response: Selective manipulation of brain CYP2B alters propofol effects. Neuropsychopharmacology. 36(3):692-700. 
  • Khokhar, J. Y., Miksys, S., Tyndale, R. F. 2010. Rat brain CYP2B induction by nicotine is persistent and does not involve nicotinic acetylcholine receptors. Brain Res. 1348:1-9. 
  • Khokhar, J. Y., Ferguson, C., Zhu, A., Tyndale, R. F. 2010. Pharmacogenetics of drug dependence: Role of gene variations in susceptibility and treatment. Annu. Rev. Pharmacol. Toxicol. 50:39-61.
  • Yue J.*, Khokhar J. Y.*, Miksys S., Tyndale R. F. 2009. Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake. Eur J Pharmacol 609: 88-95