Jibran Khokhar

B.Sc. (Queen's), Ph.D (Toronto)

jkhokhar@uoguelph.ca

Research Interests

• Neurobiology of co-occurring schizophrenia and substance use disorders
• Combining pharmacological, behavioural and pre-clinical neuroimaging methods to develop novel medications for use in "dual-disorder" patients
• Uncovering the long-term effects of adolescent drug use, and how these effects might contribute to the risk for serious mental illness and addiction
• Assessing the neurobiological effects of pesticide contamination in drugs of abuse (e.g., cannabis)

Links

www.khokharlab.com

Selected Publications

• Wallin, D. J., Sullivan, E. D. K., Bragg, E. M., Khokhar, J. Y., Lu, H., Doucette, W. T., Acquisition of resting-state functional magnetic resonance imaging data in the rat. JoVE (Accepted)
• Buckhalter, S., Soubeyrand, E., Ferrone^, S.A.E., Rasmussen, D.J., Manduca^, J.D., Al-Abdul Wahid^, S., Frie, J.A., Khokhar, J. Y., Akhtar, T.A., Perreault, M.L., The antidepressant-like and analgesic effects of kratom alkaloids are accompanied by changes in low frequency oscillations but not ΔFosB accumulation. Front Pharmacol (Accepted)
• McKie, G.L., Shamshoum, H., Hunt, K.L., Thorpe, H.H.A., Dibe, H.A., Khokhar, J. Y., Doucette, C.A., Wright, D.C., Intermittent Cold Exposure Improves Glucose Homeostasis Despite Exacerbating Diet-Induced Obesity in Mice Housed at Thermoneutrality. J Physiol (Accepted).
• Theriault, R.K., St-Denis, M., Hewitt, T. Khokhar, J. Y., Lalonde, J., Perreault, M.L., Sex-specific cannabidiol- and iloperidone-induced neuronal activity changes in an in vitro MAM model system of schizophrenia. Int. J. Mol. Sci. 2021, 22(11), 5511; doi: 10.3390/ijms22115511
• Henricks A. M., Sullivan E. D., Khokhar J. Y., 2021. In Memoriam-Alan Ivan Green, MD (1943-2020). J Dual Diagn. 2021 Apr 1:1-2. doi: 10.1080/15504263.2021.1904176.
• Oleson E. B., Khokhar J. Y. Cannabinoids: Emerging developments in neuropsychopharmacology and biological psychiatry. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 15:110305. doi: 10.1016/j.pnpbp.2021.110305
• Renda, B., Andrade, A., Stone, A. P., El Azali, R., Sharivker, M., Khokhar, J. Y., Antenos, M., Murray, J. E., Adolescent nicotine and footschock exposure augments adult nicotine self-administration and drug-seeking withouth affecting baseline anxiety-like behaviour or stress responsivity in male rats. Psychopharmacology 2021 Mar 1. doi: 10.1007/s00213-021-05803-0.
• Misner, M., Taborek, A., Sharifi, L., Khokhar, J. Y., Favetta, L. A., 2021, Effects of delta-9 tetrahydrocannabinol (THC) on oocyte competence and early embryonic development. Front. Toxicol. doi: 10.3389/ftox.2021.647918
• Jenkins, B. W. and Khokhar, J. Y., 2021, Cannabis Use and Mental Illness: Understanding Circuit Dysfunction Through Preclinical Models. Front Psychiatry Feb 5;12:597725. doi: 10.3389/fpsyt.2021.597725.
• Thorpe, H. H. A., Talhat, M. A., Khokhar, J. Y., 2020, High Genes: Genetic Underpinnings of Cannabis Use Phenotypes. Prog Neuropsychopharmacol Biol Psychiatry 10.1016/j.pnpbp.2020.110164.
• Hamidullah, S. A., Lutelmowski, C. D., Creighton, S.D., Luciani, K. R., Frie, J. A., Winters, B. D., Khokhar, J. Y., 2020. Effects of vapourized THC and voluntary alcohol drinking during adolescence on cognition, reward, and anxiety-like behaviours in rats. Prog Neuropsychopharmacol Biol Psychiatry 10.1016/j.pnpbp.2020.110141.
• Frie, J. A., Underhill, J., Zhao, B., de Guglielmo, G., Tyndale, R. F., Khokhar, J. Y., 2020. OpenVape: an Open-Source E-Cigarette Vapour Exposure Device for Rodents. eNeuro Oct 28;7(5):ENEURO.0279-20.2020. Highlighted in Research Highlights
• Mielnik, C. A., Sugamori, K. S., Mustafa, M. A., Finlay, D. A., Thorpe, H. A., Schapira, M., Sivanathan, N., Kit, L. C., Lam, V. M., Pondelick, A., Harrington, S., Abdelrahman, M. H., Trembleau, L. A., Burnham, W. M., Khokhar, J. Y., Salahpour, A., Ramsey, A. J., Glass, M., Lichtman, A., Greig, I. R., Ross, R. A., 2020. Novel Allosteric Modulator of Cannabinoid CB1 Ameliorates Hyperdominergia Endophenotypes in Rodent Models. Neuropsychopharmacology; 46(2):413-422.
• Renda, B.*, Andrade, A.*, Frie, J. A.*, Sgarbossa, C., Murray, J. E.*, Khokhar, J. Y.*, 2020. High-dose adolescent nicotine exposure permits spontaneous nicotine self-administration in adult male rats. Drug Alcohol Depend. Oct 1;215:108215
• Hamidullah, S. A., Thorpe, H. H. A., Frie, J. A., McCurdy, R. D., Khokhar, J. Y., 2020. Adolescent Substance Use and the Brain: Behavioral, Cognitive and Neuroimaging Correlates. Front Hum Neurosci. Aug 4;14:298.
• Luciani, K. L., Frie, J. A. Khokhar, J. Y., 2020. An Open Source Automated Bar Test for Measuring Catalepsy in Rats. eNeuro. Jun 19;7(3). Highlighted in Research Highlights
• Theriault, R. K., Manduca, J. L., Blight, C. R., Khokhar, J. Y., Akhtar, T. A., Perreault, M. L., 2020. Acute mitragynine administration suppresses cortical oscillatory power and systems theta coherence in rats. J Psychopharmacol. 2020 Apr 4:269881120914223
• Thorpe, H. H. A., Hamidullah, S. A., Jenkins, B. W. Khokhar, J. Y., 2019. Neurobiological Consequences of Adolescent Substance Use: From Receptors to Behavior. Pharmacol Ther. Nov 7:107431.
• Foute-Nelong, T.*, Jenkins, B.W.*, Perreault, M.L.*, Khokhar, J.Y.*, 2019. Extended attenuation of corticostriatal power and coherence after acute exposure to vapourized δ9 tetrahydrocannabinol in rats. Can J Addiction 10(3):60-66.
• Frie, J. A. and Khokhar, J. Y., 2019. An Open Source Automated Two-Bottle Choice Test Apparatus for Rats. HardwareX. April, Volume 5, doi: 10.1016/j.ohx.2019.e00061