Tony Hayes

BVSc Melbourne; PhD Saskatchewan; Diplomate ACVP

ahayes@uoguelph.ca

Research Interests

• Lectins and innate resistance to bacterial infection
• Liver disease
• Environmental hepatocarcinogenesis
• Toxicological Pathology

Selected Publications

• Brooks AS, DeLay J, Hammermueller J, Hayes MA. Identification and Characterization of Ficolin beta in Porcine Neutrophils. Biochim. Biophys. Acta 2003. In Press.
• Brooks AS, DeLay J, Hayes MA. Purification and functional characterization of porcine plasma ficolins that binds Actinobacillus pleuropneumoniae. Dev. Comp. Immunol. 27:835-844, 2003.
• Brooks, AS, DeLay J, Hayes MA. Characterization of porcine plasma ficolins that bind Actinobacillus pleuropneumoniae Serotype 5b. Immunobiology 207:1-11, 2003.
• Weebadda, WKC, Hoover GJ, Hunter DB, Hayes MA. Avian respiratory tract and serum proteins that bind surface oligosaccharides of Escherichia coli 02. Comp. Biochem. Physiol. B Biochem. Mo.l Biol. 2001, 130:299-312.
• Golovan SP, Hayes MA, Phillips JP, Forsberg CW. Transgenic mice expressing bacterial phytase as a model for phosphorus pollution control. Nat. Biotechnol. 19:429-433, 2001.
• Golovan SP, Meidinger RG, Ajakaiye A, Cottrill M, Wiederkehr MZ, Barney D, Plante C, Pollard J, Fan MZ, Hayes MA, Laursen J, Hjorth JP, Hacker RR, Phillips JP, Forsberg CW. Pigs expressing salivary phytase produce low phosphorus manure. Na.t Biotechnol. 19:741-745, 2001.
• Simko E, Hoover GJ, Kocal TE, Byrne PW, Ferguson HW, Hayes MA. Influences of Aeromonas salmonicida lipopolysaccharide, prednisone and water temperature on plasma protein composition of rainbow trout. J. Fish Dis. 22:91-100, 1999
• Simko E, El-Mowafi A, Bettger BJ, Ostland VO, Ferguson HW, Hayes MA. Alterations in iron, zinc and major plasma proteins in rainbow trout and brook trout with sterile peritonitis induced by furunculosis vaccines. J. Fish Diseases 22:81-90, 1999
• Hayes MA, Kirby GM. Neoplastic and inflammatory liver diseases of white suckers as indicators of environmental impacts. In: Impact Assessment of Hazardous Aquatic Contaminants: Concepts and Approaches. Ed S. Rao. Ann Arbor Press, 1999.
• Hoover GJ, El-Mowafi A, Simko E, Kocal TE, Ferguson HW, Hayes MA. Plasma proteins of rainbow trout (Oncorhynchus mykiss) isolated by binding to lipopolysaccharide from Aeromonas salmonicida. Comp Biochem Physiol. Part B 120:559-569, 1998
• Cote N, Trout DR, Hayes MA. Interaction of transforming growth factor beta-1 with alpha-2-macroglobulin from normal and inflamed equine joints. Can J. Vet Res 62:279-286, 1998.
• Hayes MA. Carcinogenesis. In: A Systems Approach to Veterinary Toxicology. VR Beasley. University of Illinois,. pp 923-953. 1997.
• Cheryk LA, Gentry PA, Hayes MA. Modulation of bovine platelet function by C-reactive protein. Vet Immunol Immunopathol 52: 27-36, 1996.
• Cote N, Trout D. Hayes MA. 1995. Inteactions of cytokines with alpha-2-macroglobulin in normal and horses and horses with endotoxemic signs. Can J. Vet Res 60: 150-157.
• Kirby GM, Stalker MJ, Gordon S, van Schooten FJ, Hayes MA. 1995. Influences of chronic cholangiohepatitis and cholestasis on hepatic metabolism of benzo[a]pyrene in white suckers from industrially-polluted areas of Lake Ontario. Carcinogenesis 16:2923-2929.
• Rao SS, Quinn BA, Burnison BK, Hayes MA, Metcalfe CD. 1995. Assessment of genotoxic potential of pulp mill effluent using bacterial, fish and mammalian assays. Chemosphere 31:3553-3566.
• Stalker MJ, Towner RA, Kocal TE, Quinn BA, Cameron RG, Hayes MA. 1994. Influences of dietary deoxycholic acid on progression of hepatocellular carcinomas and expression of glutathione S-transferases in rats. Toxicol Pathol 22:579-588.
• Stalker MJ, Kocal TE, Quinn BA, Gordon SG, Hayes MA. 1994. Reduced expression of glutathione S-transferase Yb2 during progression of chemically-induced hepatocellular carcinomas in Fischer 344 rats. Hepatology 20: 149-158.
• Kwiecien JM, Little PB, Hayes MA. 1994. Adherence of Haemophilus somnus to tumor necrosis factor-beta- stimulated bovine endothelial cells in culture. Can J. Vet Res. 58:211-219.
• Gonias SL, LaMarre J, Crookston KP, Webb DJ, Wolf BB, Lopes MBS, Moses HL, Hayes MA. 1994. alpha 2-Macroglobulin and the a2-macroglobulin receptor/LRP: A growth regulatory axis. Ann N.Y. Acad. Sci. 737: 273-290.
• Wollenberg GK, LaMarre J, Hayes MA. Cytokine Interactions with a2 -Macroglobulin. 1993. In: "Multiple Organ Failure: Hepatic Regulation of Host Defences" Ed. G. Matuschak. Marcel Dekker, Inc, New York, pp 293-320.

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