Intranet

Khalil Karimi

Khalil Pic

Adjunct Faculty - Research Associate and Associate Graduate Faculty

 DVM (Shiraz), PhD (Utrecht)

 kkarimi@uoguelph.ca
 Office: PAHL 3845
 519-824-4120 Ext. 54668

 Lab: PAHL 3808
 519-824-4120 Ext. 53616

 

Research Interests

My research addresses micro-environmental cues that affect components of natural defense, namely the innate immune system and how it may influence the physiological conditions and development of diverse pathophysiological responses. I have focussed on dissecting the cellular and immunological events that modulate innate immune cell component functions under various physiologic and pathophysiologic conditions.

Topics of research projects include:

  • Immunobiology of innate immune components such as dendritic cells, Natural killer cells, and neutrophils
  • Mechanisms of innate immunity in Lung
  • Modulation of innate lymphoid cells by myeloid cells in cancer, infection and inflammation
  • Dendritic cell-based vaccine

Selected Publications

  • Stegelmeier AA, van Vloten JP, Mould RC, Klafuric EM, Minott JA, Wootton SK, Bridle BW, Karimi K. (2019). Myeloid Cells during Viral Infections and Inflammation.Viruses.11(2): 168.
  • van Vloten JP, Santry LA, McAusland TM, Karimi K, McFadden G, Petrik JJ, Wootton SK, Bridle BW (2019) Quantifying Antigen-Specific T Cell Responses When Using Antigen-Agnostic Immunotherapies. Molecular Therapy - Methods & Clinical Development, Vol. 13, p154–166. Impact Factor: 3.681
  • Neumann K, Karimi K, Meiners J, Voetlause R, Steinmann S, Dammermann W, Lüth S, Asghari F, Wegscheid C, Horst AK, Tiegs G (2017) A Proinflammatory Role of Type 2 Innate Lymphoid Cells in Murine Immune-Mediated Hepatitis. J immunol. DOI: 10.4049/jimmunol.1600418. Impact Factor: 4.985
  • Thieme R, Hoffmann J, Engels G, Resa-Infante P, Alawi M, Grundhoff A, Indenbirken D, Sirignano MN, Muzzio D, Jensen F, Altfeld M, Karimi K, Mittrücker H, Arck PC, Gabriel G (2017) Pregnancy-related immune adaptation promotes the emergence of highly virulent H1N1 strains in allogenically-pregnant mice. Cell Host Microbes. 2017 Mar 8;21(3):321-333. doi: 10.1016/j.chom.2017.02.020. Impact Factor 12.552
  • Mian F, Kandiah N, Chew M, Ashkar A, Bienenstock J, and Forsythe P, Karimi K (2016) A probiotic provides protection against acute salmonellosis in mice: Possible role of innate lymphoid NKP46+ cells. J of Functional Foods. 10.1016/j.jff.2016.02.020. Impact Factor: 3.973
  • Solano ME, Kowal MK, O’Rourke GE, Horst AK, Modest K, Plösch T, Barikbin R, Remus CC, Berger RG, Jago C, Ho H, Sass G, Parker VJ, Lydon JP, DeMayo FJ, Hecher K, Karimi K, Arck PC (2015) Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation. J Clin Invest. 1;125(4):1726-38. doi: 10.1172/JCI68140. Epub 2015 Mar 16. Impact Factor: 13.765
  • Karimi K, Keßler T, Thiele K, Ramisch K, Erhardt A, Huebener P, Barikbin R, Arck P, Tiegs G (2014) Prenatal Acetaminophen induces liver toxicity in dams, reduces fetal liver stem cells, and increases airway inflammation in adult offspring. J Hepatol. 2014 Dec 18. pii: S0168-8278(14)00941-6. doi: 10.1016/j.jhep.2014.12.020. Impact Factor: 10.401
  • Wegscheid C, Karimi K, Tiegs G (2014) Hepatic CD141⁺IFNλ⁺ DC subset: one against all? J Hepatol. Jan;60(1):9-11. doi: 10.1016/j.jhep.2013.10.007. Impact Factor: 9.858
  • Chau J, Moza D, Lee J, Bienenstock J, Karimi K (2013) Increased Production of IFN-γ by Natural Killer Cells Triggered with Bone Marrow-Derived Dendritic Cells Cultured in the Presence of Retinoic Acid. Eur J Pharmacol. 715(1-3):321-7. doi: 10.1016/j.ejphar.2013.04.050. Impact Factor: 2.728
  • Karimi K, Forsythe P (2013) Natural Killer Cells in Asthma. Frontiers in Immunology. Jun 21;4:159. doi: 10.3389/fimmu.2013.00159. Impact Factor: 4.71
  • Karimi K, Kandiah N, Chau J, Bienenstock J, and Forsythe P. (2011) A Lactobacillus rhamnosus Strain Induces a Heme Oxygenase Dependent Increase in Foxp3+ Regulatory T Cells. PLOS ONE. 2012;7(10):e47556. doi: 10.1371/journal.pone.0047556. Epub 2012 Oct 15. Impact Factor: 4.573
  • Karimi K, Solano ME, Ashkar A, Huang H, Steidle E, Neufeld KA, Hecher K, Bienenstock J, Arck CP (2011) Regulation of pregnancy maintenance and fetal survival in mice by CD27low mature NK cells. Journal of Molecular Medicine. 2012 Sep;90(9):1047-57. Impact Factor 5.192
  • Karimi K, Inman MD, Bienenstock J, Forsythe P. (2009) Lactobacillus reuteri Induced Regulatory T Cells Protect Against an Allergic Airway Response in Mice. Am J Respir Crit Care Med. 1;179(3):186-93. Impact Factor: 10.689
  • Karimi K, Arck PC. (2009) Natural Killer Cells: Keepers of Pregnancy in the Turnstile of the Environment. Brain Behav Immun. 2010 Mar;24(3):339-47. Impact Factor: 5.061
  • Karimi K, Boudreau J, Fraser K, Liu H, Delanghe J, Bernard D, Xing Z, Bramson J, Gauldie J, and Wan Y. (2008) Enhanced Antitumor Immunity Elicited by Dendritic Cell Vaccines Is a Result of Their Ability to Engage Both CTL and IFNgamma-producing NK Cells. Molecular Therapy. 16(2):411-8. Impact Factor: 6.239
  • Karimi K, Blois SM, Arck PC. (2008) The Upside of Natural Killer Cells. Nat Med. 14(11):1184-5. Impact Factor: 27.136
  • Karimi K, Redegeld FA, Heijdra B and Nijkamp FP. (1999) Stem Cell Factor and Interleukin-4 Induce Murine Bone Marrow Cells to Develop into Mast Cells with Connective Tissue Type Characteristics in Vitro. Exp Hematol. 27:654-62. Impact Factor: 3.106
  • Seifi HA, Karimi K, and Movasseghi AR. (1997) Renal amyloidosis in cattle: a case report in Iran. J. Vet. Med. B 44, (10):631-3. Impact Factor: 1.48

Search PubMed for additional publications by Dr. Karimi.