Research Interests

Anatomic pathology: oncologic pathology, mechanisms of metastasis and chemoresistance, cancer prognostication, osteosarcoma

Graduate Students

Rachael Speare

PhD

Janak Khopkar

MBS

Mafalda Casa Nova

DVSc

Emma Vanderboon

MSc

Selected Publications

 C.R. Schott, A.L. Koehne, L.C. Sayles, E.P. Young, C. Luck, K. Yu, A.G. Lee, M.R. Breese, S.G. Leung, H. Xu, A.T. Shah, H. Liu, A. Spillinger, I.H. Behroozfard, K.D. Marini, P.T. Dinh, M.V. Pons Ventura, E.N. Vanderboon*, F.K. Hazard, S. Cho, R.S. Avedian, D.G. Mohler, M. Zimel, R. Wustrack,  C. Curtis, M. Sirota, E.A. Sweet-Cordero. Development and characterization of new patient-derived xenograft (PDX) models of osteosarcoma with distinct metastatic capacities. bioRxiv. 2023. doi: https://doi.org/10.1101/2023.01.19.524562

A. Matsuyama, G.A. Wood, R. Speare*, C.R. Schott, A.J. Mutsaers. Prognostic significance of the urokinase plasminogen activator system in tissue and serum of dogs with appendicular osteosarcoma. PLoS One. 2022 Sep 29;17(9):e0273811.

C. Schott, A.T. Shah, E.A. Sweet-Cordero. (2020) Genomic Complexity of Osteosarcoma and Its Implication for Preclinical and Clinical Targeted Therapies. In: Kleinerman E., Gorlick R. (eds) Current Advances in the Science of Osteosarcoma. Advances in Experimental Medicine and Biology, vol 1258. Springer, Cham.

K. Wong, L. van der Weyden, C.R. Schott, M.J. Arends, A. Foote, F. Constantino-Casas, S. Smith, J.M. Dobson, E. Murchison, H. Wu, I. Yeh, D.R. Fullen, N. Joseph, B.C. Bastian, R.M. Patel, I. Martincorena, D. Robles Espinoza, V. Iyer, T. Brenn, P. Harms, G.A. Wood, D.J. Adams. The cross-species genomic landscape of human mucosal, canine oral and equine melanoma. Nat Commun. 2019; 10(1): 353-366

C.R. Schott, L. Ludwig, A.J. Mutsaers, R.A. Foster, G.A. Wood. The autophagy inhibitor spautin-1, either alone or combined with doxorubicin, decreases cell survival and colony formation in canine appendicular osteosarcoma cells. PLoS One. 2018; 13(10): e0206427

A.K. Luu, C.R. Schott, R. Jones, A.C. Poon, B. Golding, R. Hamed, B. Deheshi, A. Mutsaers, G.A. Wood, A.M. Viloria-Petit. An evaluation of TAZ and YAP crosstalk with TGFβ signalling in canine osteosarcoma suggests involvement of hippo signalling in disease progression. BMC Vet Res. 2018; 14: 365

A. Matsuyama, C.R. Schott, G.A. Wood, D. Richardson, P. Woods, A.J. Mutsaers. Evaluation of metronomic cyclophosphamide in dogs with appendicular osteosarcoma as maintenance therapy following amputation and carboplatin chemotherapy. J Am Vet Med Assoc. 2018; 252(11): 1377-1383

C.R. Schott, L.J. Tatiersky, R.A. Foster, G.A. Wood. Histologic grade does not predict outcome in dogs with appendicular osteosarcoma receiving the standard of care. Vet Pathol. 2018; 55(2): 202-211

C.R. Schott, H.Y. Cai, L. Parker, K.G. Bateman, J.L. Caswell. Hydrogen peroxide production and free radical-mediated cell stress in Mycoplasma bovis pneumonia. J Comp Pathol. 2014; 150(2-3): 127-137  

K. Taha-Abdelaziz, J. Perez-Casal, C.R. Schott, J. Hsiao, S. Attah-Poku, D. Slavić, J.L. Caswell. Bactericidal activity of tracheal antimicrobial peptide against respiratory pathogens of cattle. Vet Immunol Immunopathol. 2013; 152(3-4): 289-294

F. Castillo-Alcala, K.G. Bateman, H.Y. Cai, C.R. Schott, L. Parker, M.E. Clark, P. McRaild, R.M. McDowall, R.A. Foster, M. Archambault, J.L. Caswell. Prevalence and genotype of Mycoplasma bovis in beef cattle after arrival at a feedlot. Am J Vet Res. 2012; 73(12): 1853-1857

Search PubMed for additional publications by Dr. Schott.