Brandon Lillie

DVM, PhD, Diplomate ACVP

blillie@uoguelph.ca
Office: PAHL 3824
519-824-4120 Ext. 54667

Lab: PAHL 3813
519-824-4120 Ext. 54665

@DeadAnimalDoc
Brandon Lillie on LinkedIn
Brandon Lillie on ResearchGate
Brandon Lillie on Academia
 Brandon Lillie on ORCiD

Research Interests

• Genetics of disease
• Innate disease resistance in production animals
• Collagenous lectins, peptidoglycan recognition proteins, and other pattern recognition molecules
• Equine infectious diseases
• Equine reproductive failure (spontaneous and EHV-associated)
• Crimean-Congo Hemorrhagic Fever Virus control in livestock - a One Health approach to controlling human and animal diseases

Current Graduate Students

• Maddison Arsenault - DVSc
• Saira Asif - MSc
• Ji Ye Ahn - DVSc
• Connor Bryant - DVSc
• Karen Carlton - DVSc
• Caitlin Evered - DVSc
• Chantelle Major - MSc
• Andrii Trokoz - DVSc

OTHER LAB PERSONNEL

Dr. Vahab Farzan: DVM, MSc, PhD - Research Scientist

Dr. Jutta Hammermueller: BSc, PhD - Research Technician

Maria Papapetrou: BSc, DVM student (class of 2024) - Undergraduate Research Student

FORMER GRADUATE STUDENTS:

• Jeremy Wong, BSc (Western), MSc - Graduated S20
  • Investigating single-nucleotide variants in swine associated with common infectious pathogens and diseases, with a focus on Streptococcus suis infection, using a genome-wide association study approach
• Elana Raaphorst, BSc (Guelph), MSc - Graduated S20
  • Antibody responses to porcine reproductive and respiratory syndrome virus, influenza A virus, and Mycoplasma hyopneumoniae and their association with single-nucleotide variants
• Corinne Schut, BSc (Guelph), MSc - Graduated W18
  • Salmonella antibody response on commercial swine farms and its association with host genetics and isolation of Salmonella on-farm and at slaughter
• Russell Fraser, BSc.H (Guelph), DVM (Guelph), MSc (Edinburgh), PhD - GRADUATED  S'18
  • Investigation of genetic variation in the collagenous lectins of livestock with and without infectious diseases
• Margaret Ainslie-Garcia, BSc.H (Guelph). MSc - GRADUATED  W’17
  • An epidemiological study of the effect of diet and innate immune genotype on Salmonella shedding and colonization in pigs
• Kristin Wythe, BSc.H (Guelph). MBS - GRADUATED  S’16
  • Discovery of genetic variants in equine peptidoglycan recognition proteins using a targeted next generation sequencing approach
• ​Abqara Abida, BSc (University of Sindh), MSc (University of Sindh). MBS - GRADUATED S’15
  • Expression of peptidoglycan recognition proteins (PGLYRP-1 and PGLYRP-2) in male and female porcine tissue
• Heindrich Snyman, BVSc (University of Pretoria). DVSc - GRADUATED F’13
  • Constitutive variation in hepatic expression of porcine innate immune genes associated with novel promoter polymorphisms
• Ola Sawicka, BSc (Guelph). MBS - GRADUATED S’13
  • Discovery of single and interaction effects for novel innate immune single nucleotide polymorphisms in swine
• ​Iga Stasiak BSc (Windsor), DVM (Guelph). DVSc - GRADUATED F’12
  • The role of hepcidin in regulation of iron balance in bats.
• David Balogh, BSc.H (Guelph). MBS - GRADUATED S’12
  • Promoter region single nucleotide polymorphisms and variable expression of the peptidoglycan recognition protein 1 and 2 genes in pigs.

Research Interests

Teaching

Undergraduate

• TOX*4100 Toxicological Pathology
• VETM*4490 Systems Pathology
• VETM*4620/4680/4940/4720 Health Management: Anatomic Pathology rotation

Graduate

• BIOM*6800 Gene Expression in Health and Disease
• PABI*6104 Mechanisms of Disease: Course Co-Coordinator
• PABI*6080 Diagnostic Pathology I
• PABI*6090 Diagnostic Pathology II
• PABI*6091 Diagnostic Pathology III

Selected Publications

Search PubMed for additional publications by Dr. Lillie.

For an up to date listing of publications, please visit Dr. Lillie's Google Scholar page

• Balmori-Cedeno J, Liu J, Misk E, LILLIEBN, & Lumsden JS. (2019).  Autophagy-related genes in rainbow trout Oncorhynchus mykiss (Walbaum) gill epithelial cells and their role in nutrient restriction.   Journal of Fish Diseases, 42 (4)., doi: doi: 10.1111/jfd.12959.
• Di Natale A, Jarau M, Russell SK, Horricks RA, Lillie BN, Dixon B, Lumsden JS. (2019).  Rainbow trout Oncorhynchus mykiss (Walbaum) type IV ice-structuring protein LS-12 in the acute phase response to Flavobacterium psychrophilum infection.   Journal of Fish Diseases., doi: 10.1111/jfd.13002.
• Brochu NM, Guerin MT, Varga C, Lillie BN, Brash ML, Susta L. (2019).  A 2-year Prospective Study of Ontario, Canada Small Flocks: Part 1 - Prevalence of Viral and Bacterial Pathogens.   Journal of Veterinary Diagnostic Investigation, 31 (3), 327-335, doi: 10.1177/1040638719843577.
• Brochu NM, Guerin MT, Varga C, Lillie BN, Brash ML, Susta L. (2019).  A 2-year Prospective Study of Ontario, Canada Small Poultry Flocks: Part 2 - Causes of Morbidity and Mortality.   Journal of Veterinary Diagnostic Investigation, 31 (3), 336-342, doi: 10.1177/1040638719843575.
• Schut CH, Farzan V, Ainslie-Garcia MH, Friendship RM, & LILLIEBN. (2019).  Antibody Responses to Salmonellain Pigs from Weaning up to Marketing and Presence of Salmonella at Slaughter.   Foodborne Pathogens and Disease, 16 (3), 187-194, doi: 10.1089/fpd.2018.2454.
• Horricks RA, Herbinger CM, LILLIE BN, Taylor P, & Lumsden JS. (2019).  Differential protein abundance during the first month of regeneration of the Caribbean star coral Montastraea cavernosa.   Coral Reefs, 38 (1), 45-61, doi: https://doi.org/10.1007/s00338-018-01754-9.
• Léveillé AN, Bland SK, Carlton K, Larouche CB, Kenney DG, Brouwer ER, Lillie BN, Barta JR. (2019). Klossiella equi Baumann, 1946 infecting kidneys of Ontario horses: Life cycle features and multi locus sequence based genotyping confirm the genus Klossiella belongs in the Adeleorina (Apicomplexa: Coccidia).   Journal of Parasitology, 105 (1), 29-40, doi: 10.1645/18-80.
• Ainslie-Garcia MH, Farzan A, Newman JE, Friendship RM, Lillie BN. (2018).  Salmonella fecal shedding in pigs from birth to market and its association with the presence of Salmonella in palatine tonsils and submandibular lymph nodes at slaughter.  Canadian Journal of Veterinary Research, 82 (4), 249-255.
• Bourque LA, Raverty S, Co C, Lillie BN, Daoust PY, Clark ME, Caswell JL. (2018).  Benzo(a)pyrene suppresses tracheal antimicrobial peptide gene expression in bovine tracheal epithelial cells.   Veterinary Immunology and Immunopathology, 203, 40-46, doi: https://doi.org/10.1016/j.vetimm.2018.08.001.
• Fraser RS, Lumsden JS, Lillie BN. (2018).  Identification of polymorphisms in the bovine collagenous lectins and their association with infectious diseases in cattle.   Immunogenetics, 70 (8), 533-546, doi: https://doi.org/10.1007/s00251-018-1061-7.
• Ainslie-Garcia MH, Farzan A, Jafarikia M, Lillie BN.. Single nucleotide variants in innate immune genes associated with Salmonella shedding and colonization in swine on commercial farms. Vet Microbiol. 2018 Jun;219:171-177. doi: 10.1016/j.vetmic.2018.04.017.
• Fraser RS, Arroyo LG, Meyer A, Lillie BN. Identification of genetic variation in equine collagenous lectins using targeted resequencing. Vet Immunol Immunopathol. 2018 Aug;202:153-163. doi: 10.1016/j.vetimm.2018.07.001.
• Stasiak IM, Smith DA, Ganz T, Crawshaw G, Hammermueller J, Bienzle D, Lillie BN. Iron storage disease (hemochromatosis) and hepcicin response to iron load in two species of pteropodid fruit bats relative to the common vampire bat. J Comp Phys B. 2018. Mar 29. doi: 10.1007/s00360-018-1155-4. [Epub ahead of print]
• Arroyo LG, Costa MC, Guest BB, Plattner BL, Lillie BN, Weese JS. Duodenitis-Proximal Jejunitis in Horses After Experimental Administration of Clostridium difficile Toxins. J Vet Intern Med. 2017 Jan: 31(1): 158-63. doi: 10.1111/jvim.14624.
• Kirkbright D, Huber P, Lillie BN, Lumsden JS. Dermocystidium-like organism linked with a mortality event in yellow perch Perca flavescens (Mitchill) in Ontario, Canada. J Fish Dis. 2016 May: 39(5): 597-601  doi: 10.1111/jfd.12379.
• Contador E, Methner P, Ryerse I, Huber P, Lillie BN, Frasca S Jr, Lumsden JS. Epitheliocystis in lake trout Salvelinus namaycush (Walbaum) is associated with a β-proteobacteria. J Fish Dis. 2016 Mar: 39(3): 353-66. doi: 10.1111/jfd.12369.
• Senthilkumaran C, Hewson J, Ollivett TL, Bienzle D, Lillie BN, Clark M, Caswell JL. Localization of annexins A1 and A2 in the respiratory tract of healthy calves and those experimentally infected with Mannheimia haemolytica. Vet Res. 2015 Feb 14;46:6. doi: 10.1186/s13567-014-0134-3.
• Stasiak IM, Smith DA, Crawshaw GJ, Hammermueller JD, Bienzle D, Lillie BN. Characterization of the hepcidin gene in eight species of bats. Res Vet Sci. 2014 Feb;96(1):111-7.
• Summa NM, Eshar D, Snyman HN, Lillie BN. Metastatic anaplastic adenocarcinoma suspected to be of mammary origin in an intact male rabbit (Oryctolagus cuniculus). Can Vet J. 2014 May;55(5):475-9.
• Stasiak IM, Smith DA, Crawshaw GJ, Hammermueller JD, Bienzle D, Lillie BN. Characterization of the hepcidin gene in eight species of bats. Res Vet Sci. 2014 Feb;96(1):111-7.
• Link KA, Koenig JB, Silveira A, Plattner BL, Lillie BN. Effect of unfocused extracorporeal shock wave therapy on growth factor gene expression in wounds and intact skin of horses.Am J Vet Res. 2013 Feb;74(2):324-32.