Study shows benefit of vascular normalization in OV therapy for advanced epithelial ovarian cancer

From left to right: Drs. Byram Bridle, Jim Petrik and Sarah Wootton (Photo by Karen Mantel, Ontario Veterinary College) Virologists studying the use of viruses to treat cancer have long seen acute vascular shutdown as a positive response to oncolytic virus (OV) therapy. This process, which is characterized by the drastic reduction of blood flow to a tumour after treatment, was believed to make OV treatment more effective by increasing oxygen starvation in cancer cells and sequestering the viruses within the tumours.  | The Terry Fox Research Institute