Dr. Matthew Vickaryous

Ontario Veterinary College

Department of Biomedical Sciences


Email: mvickary@uoguelph.ca

Office: OVC 2624

Ext: 53871

 

 

 

Research conducted by the Vickaryous Lab uses geckos and other organisms to study naturally evolved mechanisms of wound healing, regeneration, and development. Ongoing work includes the study of scar-free cutaneous wound healing, neurogenesis, spinal cord regeneration, and cardiac repair.  

The Vickaryous Lab takes great pride in great histology. Related to this, we are closely allied with the Histoprep Laboratory in Biomedical Sciences.  The primary model for our research is the leopard gecko. In addition, we use embryonic chicks and alligators, as well as other lizard species. Current collaborations: Dr. J. Petrik (role of VEGF in scar-free wound healing); Dr. A. Viloria-Petit (role of TGFbeta in regeneration); Dr. C. Holliday, UMissouri (cranial joint development).

     Recent publications relating to regenerative medicine (2012-present):

  1. Payne, S. L., Peacock, H.M. & Vickaryous, Matthew K. (in press). Blood vessel formation during tail regeneration in the leopard gecko (Eublepharis macularius): the blastema is not avascular. Journal of Morphology
  2. Vickaryous, Matthew K., *Meldrum, G. L., & Russell, A. P. (2016). Armored geckos: a histological investigation of osteoderm development in Tarentola (Phyllodactylidae) and Gekko (Gekkonidae) with comments on their regeneration and inferred function. Journal of Morphology, 276 (11), 1354-1357.
  3. Gilbert, R. W., Vickaryous, Matthew K., & Viloria-Petit, A. M. (2016). Signalling by transforming growth factor beta isoforms in wound healing and tissue regeneration. Journal of Developmental Biology.
  4. Peacock, H. M., Gilbert, E. A., & Vickaryous, Matthew K. (2015). Scar-free cutaneous wound healing in the leopard gecko, Eublepharis macularius. Journal of Anatomy, 227 (5), 596-610.
  5. Gilbert, E. A., Delorme, S. L., & Vickaryous, Matthew K. (2015). The regeneration blastema of lizards: an amniote model for the study of appendage replacement. Regeneration, 2 (2), 45-53, doi: 10.1002/reg2.31.
  6. Co, C., Vickaryous, Matthew K., & Koch, T. (2014). Membrane culture and reduced oxygen tension enhances cartilage matrix formation from equine cord blood mesenchymal stromal cells in vitro. Osteoarthritis and Cartilage, 22 (3), 472-480.
  7. Gilbert, E. A., Payne, S. L., & Vickaryous, Matthew K. (2013). The anatomy and histology of autotomy and regeneration in lizards. Physiological and Biochemical Zoology, 86 (6), 631-644, doi: 10.1086/673889.
  8. Gilbert, R. W., Vickaryous, Matthew K., & Viloria-Petit, A. (2013). Characterization of TGFbeta signaling during multi-tissue regeneration in the leopard gecko. Developmental Dynamics.
  9. Delorme, S. D., Lungu, I. M., & Vickaryous, M. K. (2012). Scar-free wound healing and regeneration following tail loss in the leopard gecko. Anatomical Record, 295, 1575-1585.