Dr. Mark Hurtig

Ontario Veterinary College

Department of Clinical Studies


Email: mhurtig@ovc.uoguelph.ca

Ext: 54028

 

 

Dr. Hurtig’s research focuses on models to investigate human and animal disease progression, specifically bone and cartilage injuries that lead to knee arthritis.  Past equine-related work includes fetlock osteoarthritis and cannon bone fractures in racehorses as well as non-invasive methods of detecting incipient injuries. Dr. Hurtig’s current research is focused on new pharmaceutical, biomaterial and cell-based therapies for treatment of cartilage and bone injuries.

Our lab uses animal species such as the rat, minipig and sheep to investigate drug, therapeutic protein and laboratory-grown engineered tissue for repair of joint injuries. Starting with mathematical (FEA) modeling and in vitro screening of cartilage explants we work toward creating a model of therapy in animals that can be extrapolated to human patients. MicroCT imaging, biomechanical testing, tissue biochemistry, morphometry and immunohistochemistry are used. Current collaborations include: University of Toronto, University Health Network (Toronto), University of Calgary, Brown University, Harvard University, University of Southern California and several industrial collaborations.

     Recent publications relating to regenerative medicine (2012-present):

  1. Deprés-Tremblay G, Chevrier A, Snow M, Hurtig MB, Rodeo S, Buschmann MD. Rotator cuff repair: a review of surgical techniques, animal models, and new technologies under development. J Shoulder Elbow Surg. 2016 Dec;25(12):2078-2085.
  2. Gignac MA, Cao X, Ramanathan S, White LM, Hurtig M, Kunz M, Marks PH.  Perceived personal importance of exercise and fears of re-injury: a longitudinal  study of psychological factors related to activity after anterior cruciate ligament reconstruction. BMC Sports Sci Med Rehabil. 2015 Jan 21;7:4.

  3. Lee WD, Hurtig MB, Pilliar RM, Stanford WL, Kandel RA. Engineering of hyaline cartilage with a calcified zone using bone marrow stromal cells. Osteoarthritis Cartilage. 2015 Aug;23(8):1307-15

  4. Kroell A, Marks P, Chahal J, Hurtig M, Dwyer T, Whelan D, Theodoropoulos J. Microfracture for chondral defects: assessment of the variability of surgical technique in cadavers. Knee Surg Sports Traumatol Arthrosc. 2014 Dec 23.

  5. Kahlon A, Hurtig MB, Gordon KD. Regional and depth variability of porcine meniscal mechanical properties through biaxial testing. J Mech Behav Biomed Mater. 2014 Oct 19;41C:108-114.

  6. Chevrier A, Kouao AS, Picard G, Hurtig MB, Buschmann MD. Interspecies comparison of subchondral bone properties important for cartilage repair. J Orthop Res. 2015 Jan;33(1):63-70.

  7. Chen L, Gordon K, Hurtig M. Design and validation of a cadaveric knee joint loading device compatible with magnetic resonance imaging and computed tomography. Med Eng Phys. 2014 Oct;36(10):1346-51

  8. Hoemann CD, Gosselin Y, Chen H, Sun J, Hurtig MB, Carli A, Stanish WD. Influence of microfracture awl geometry, lesion grade, and subchondral sclerosis, on bone damage and marrow access in osteoarthritic femoral condyles.  Submitted, Arthritis & Rheumatism, Sept 14, 2012