Ontario Veterinary College
Department of Clinical Studies
Dr. Koenig’s main area of research is in tissue regeneration and healing, with emphasis on wound and tendon healing in horses. Investigation of different modalities for tissue regeneration and wound healing, such as allogeneic cord blood stem cells, low level light lasers and shock wave treatment. These modalities accelerate the healing process through interacting with different cellular pathways. Research has been done to investigate the effect of low level light lasers and shock waves on wound healing in horses. Also, the antiinflammatory properties of allogeneic cord blood stem cells on induced synovitis in horses has been demonstrated. The effect of repeated administration of stem cells in the treatment of superficial digital flexor tendinitis is currently evaluated. Another current area of research is the effect of shockwave application on stem cells.
My main role in our research team is as a clinician and surgeon. As clinician I usually design and participate in the in vivo trials, either using animal models or clinical cases. I do not have my on lab, but collaborate with Dr Koch and our graduate students are trained in his lab.
Recent publications relating to regenerative medicine (2012-present):
- Williams LB, Co C, Koenig JB, Tse C, Lindsay E, Koch TG. Response to Intravenous Allogeneic Equine Cord Blood-Derived Mesenchymal Stromal Cells Administered from Chilled or Frozen State in Serum and Protein-Free Media. Front Vet Sci. 2016 Jul 22;3:56.
- Williams LB, Russell KA, Koenig JB, Koch TG. Aspiration, but not injection, decreases cultured equine mesenchymal stromal cell viability. BMC Vet Res. 2016 Mar 7;12:45.
- Williams LB, Koenig JB, Black B, Gibson TW, Sharif S, Koch TG. Equine allogeneic umbilical cord blood derived mesenchymal stromal cells reduce synovial fluid nucleated cell count and induce mild self-limiting inflammation when evaluated in an lipopolysaccharide induced synovitis model. Equine Vet J. 2016 Sep;48(5):619-25.
- Williams LB, Tessier L, Koenig JB, Koch TG. Post-thaw non-cultured and post-thaw cultured equine cord blood mesenchymal stromal cells equally suppress lymphocyte proliferation in vitro. PLoS One. 2014 Dec 1;9(12):
- Bourzac CA, Koenig JB, Link KA, Nykamp SG, Koch TG. Evaluation of ultrasmall superparamagnetic iron oxide contrast agent labeling of equine cord blood and bone marrow mesenchymal stromal cells. Am J Vet Res. 2014 Nov;75(11):1010-7
- Elmas CR, Koenig JB, Bienzle D, Cribb NC, Cernicchiaro N, Coté NM, Weese JS. Evaluation of a broad range real-time polymerase chain reaction (RT-PCR) assay for the diagnosis of septic synovitis in horses. Can J Vet Res. 2013 Jul;77(3).
- Link KA, Koenig JB, Silveira A, Plattner BL, Lillie BN. Effect of unfocused extracorporeal shock wave therapy on growth factor gene expression in wounds and intact skin of horses. Am J Vet Res. 2013 Feb;74(2):324-32.
- Silveira A, Koenig JB, Arroyo LG, Trout D, Moens NM, LaMarre J, Brooks A. Effects of unfocused extracorporeal shock wave therapy on healing of wounds of the distal portion of the forelimb in horses. Am J Vet Res. 2010 Feb;71(2):229-34.