Judith Koenig

Research Interests

• ​Tissue regeneration and healing
• Osteoarthritis

Current Research

• Use of allogeneic cord blood stem cells for tissue regeneration
• Effect of shockwave on stem cells
• Effect of shockwave on wound healing in horses
• Evaluation of the significance of caudal facet arthropathy in Sports horses
• Evaluation of different medications on coffin joint osteoarthritis 
• Rehabilitation

Current Graduate Students

Rodrigo Munevar Luque (2022-present)
PhD Thesis: Comparison of the use of various allogeneic stem cell preparations in the treatment of osteoarthritis in the horse

T Connor McCorkell (2023-present)
PhD thesis: Safety and efficacy of antisense miRNA 181 in osteoarthritis in horses  

Albert Torrent (2024-present)  
MSc Thesis: Effect of activated MSC in hydrogel on tendinitis in horses  

Previous Graduate Students

Doctoral Students

Andres Giraldo (2019-2023)
DVSc Thesis: Immune modulatory effect of shockwave on stem cells

Alejandro Merchan Munoz (2018-2023)
DVSc Thesis: Treatment of naturally occurrying tendonitis in racehorses with repeated injection of allogeneic mesenchymal cells

Rames Salcedo (2015-2019)
DVSc Thesis: Effect of Extracorporeal Shock Wave Therapy on Equine Umbilical Cord Blood Mesenchymal Stromal Cells in vitro

Lynn Williams (2012-2015)
PhD Thesis: Preliminary Evaluation Of Equine Umbilical Cord Blood Mesenchymal Stromal Cells As Treatment Of Synovitis

Celine Bourzac (2010- 2013)
DVSc Thesis: Evaluation of ultrasmall superparamagnetic iron oxide contrast agent labeling of equine cord blood and bone marrow mesenchymal stromal cells

Colette Elmas (2008-2012)
DVSc Thesis: Evaluation of a broad-range real time PCR assay for the diagnosis of septic synovitis in horses

Andressa Silveira (2006-2009)
DVSc Thesis: The effect of shockwave on wound healing in horses 

MSc Students

Rodrigo Munevar Luque (2020)
MSc thesis: Use of intra-articular mesenchymal stem cells in equine osteoarthritis with a comparative approach

Juan Pineros Varga (2015)
MSc coursework project: Cervical facet osteoarthritis in horses

Christina Martin (2014)
MSc thesis: Distribution of Neurokinin 2 and 3 Receptor mRNA In the Normal Equine Gastrointestinal Tract and Effect of Inflammation on Neurokinin 1, 2, And mRNA In the Equine Jejunum 

Selected Publications

• A Bütter, E Zani-Ruttenstock, F Doktor, R Figueira, C McCorkell, D Espinosa, J Koenig, G Biouss, K Khalaj, L Antounians, A Zani, Stem cell extracellular vesicles as a regenerative therapy for hypoplastic lungs: Translational studies in CDH lamb fetuses, International Fetal Medicine & Surgery Society Annual Meeting, Ireland, Castlemartyr Conference Date: September 2024
• Giraldo A, Koch TG, Madan P, Lepage S, Monteith G, Alizadeh AH, Tran A, Mortagy N, Koenig JB. (2024). Effect of extracorporeal shockwave therapy on the immunomodulatory and anti-inflammatory properties of cultured equine umbilical cord blood mesenchymal stromal cells. Canadian Journal of Veterinary Research, 88(3), 87-93.
• Judith Koenig, Emma Chawner, Alejandro Merchan Munoz, Marta Nieto Poza, Dasiel Obregon Alvarez, Gabrielle Monteith. (2024). The Influence of Septic Arthritis-Related Bone Lysis on Prognosis in Calves. Vet Surgery 53: 4 (abstract).
• Suderman, R. P., Pascual, J., Luque, R. Munevar, Grynpas, M., Naguib, H., Koenig, J. & Changoor., A. (2024). “Non-Invasive Electroarthrography Follows Progression of Early Osteoarthritis in an Equine Chip Model and Corresponds to Clinical Outcomes Canadian Orthopedic Association. (abstract)
• Obrochta, Bartłomiej, Saitua, Aritz, Gracia Calvo, Luis, Muñoz, Encarnacion, Koenig Judith, Mendez-Angulo, Jose, Argüelles, David. (2024). Short- and long-term postoperative complications and outcomes after umbilical vein marsupialisation in 11 foals. Equine Veterinary Education. Epub
• Joshua  Antunes, Ramés Salcedo-Jiménez, Starlee Lively, Pratibha Potla, Nathalie Coté, Marie-Soleil Dubois, Judith Koenig, Thomas Gadegaard Koch. (2024). microRNAs are differentially expressed in equine plasma of horses with osteoarthritis and osteochondritis dissecans versus control horses. PLoS ONE, 19(2), e0297303. 
• Munevar Luque, R, Koch TG, Goodrich L, Giraldo A, Valverde A, Zur Linden A, Beehler Marfisi J, Koenig JB (abstract). Pooled Cord Blood Mesenchymal Stromal Cells Slow The Progression Of Osteoarthritis In An Equine Fetlock Chip Model. VCOT Open 2024; 07(S01)
• Koenig, JB, Henderson, B, Luque, RM, Alizadeh, AH, Russel, K & Koch, TG (abstract). Comparable Results with 10 Million or 20 Million Allogenic Mesenchymal Stromal Cells in Treating Synovitis in Horses.  VCOT Open 2024; 07(S07).
• Suderman, R. P., Pascual, J., Luque, R. Munevar, Grynpas, M., Naguib, H., Koenig, J. & Changoor., A. (2024). Non-invasive Electroarthrography And Centre Of Pressure Measurements Track Progression In An Equine Chip Model Of Early Osteoarthritis. In Orthopaedic Research Society. (abstract)
• L Recchi, N Cribb, N Côté, M Dubois, J Koenig, A Valverde, G Monteith. (2024). Retrospective study of perioperative antimicrobial use in horses undergoing elective laparoscopy at a single institution. Canadian Journal of Veterinary Research, 88(1). 
• Recchi L, Merchán A, Ducrocq M, Koenig J, Dubois MS, Brisson BA. (2023, November). Anoplasty and rectovaginal fistula repair in a gilt with atresia ani: A case report. Canadian Veterinary Journal, 64(11), 1009-1014. 
• Merchan Munoz, A, Beaulieu, A, Cote, N, Zur Linden, A, Koenig, J , Brooks, A. (2022, May). Use of computed tomography angiography to evaluate the vascular anatomy of a hemangioma on the lateral-plantar aspect of the metatarsophalangeal joint of a horse. Equine Veterinary Education, 34(5), 176-180. 
• Merchán A, Koenig J, Côté N, Cribb N, Monteith G. (2022). Fragment size is associated with post-operative complications following elective arthroscopy of the tibiotarsal joint of horses. Canadian Veterinary Journal, 63(1), 74-80. 
• Merchan Munoz, A, Ducrocq M, Koenig J, Cribb N & Côté N. (2022). Front Limb Lacerations of the Digital Flexor Tendon Sheath and Flexor Tendons in Standardbred Racehorses. Veterinary Surgery 51:4 (abstract)
• Merchán A, Recchi L, Brisson B, Koenig J, Dubois M. (2022, July). Atresia ani and rectovaginal fistula in a Vietnamese Potbellied pig: reconstruction of the anal canal and the anus. Veterinary Surgery 51:4 (abstract)
• Salcedo-Jiménez, R, Lee O, Koenig J (2022). Corrigendum: Extracorporeal Shock Wave Therapy Enhances the In Vitro Metabolic Activity and Differentiation of Equine Umbilical Cord Blood Mesenchymal Stromal Cells. Front Vet Sci, 9(jan 28).                    
• Beaulieu A, Nykamp S, Phillips J, Arroyo LG, Koenig J, Zur Linden A. (2021). Development and Validation of a Three-Dimensional Printed Training Model to Teach Ultrasound-Guided Injections of the Cervical Articular Process Joints in Horses. Journal of veterinary medical education, 48, e20200137.
• Merchan Munoz A, Koch T, Cote N, Hamed Alizadeh, Russel Keith, Monteith G, Koenig J. (2021). Evaluation of Repeated Intralesional Injection of Allogeneic Umbilical Equine Cord Blood Mesenchymal Stromal Cells for Treatment of Equine Superficial Digital Flexor Tendonitis. Veterinary Surgery 50:6 (abstract).
• Merchán, A, Cote, N, Mehrpoyan, S, Alizadeh, H, Koch, T & Koenig, J. (2021). Lymphocyte populations CD4+ and CD8+ response to repeated intralesional injection of superficial digital flexor tendon core lesions with Allogeneic Equine Cord Blood-Derived Mesenchymal Stromal Cells. Veterinary Surgery 50:6 (abstract).
• A Merchán, A Beaulieu, N Côté, A zur Linden, J Koenig, A Brooks (2021). Use of computed tomography angiography for the evaluation of a cutaneous haemangioma in a Standardbred horse. Equine Veterinary Education epub ahead
• Henderson, B Bramlage, L Koenig, J* Monteith, G. (2020). Postinjury performance for differing humeral stress fracture locations in the racing thoroughbred. Veterinary Surgery. 49(7): 1412-1417
• Martin, C Koenig, J* Campbell, N Lamarre, J Sonea, I. (2020). Distribution of Neurokinin 2 and 3 Receptor mRNA In the Normal Equine Gastrointestinal Tract and Effect of Inflammation on Neurokinin 1, 2, And 3 Receptor mRNA In the Equine Jejunum. Global Journal of Veterinary Care and Research. 2(1): 1-13.
• Koenig JB*, Westlund A, Nykamp S, Kenney DG, Melville L, Cribb N, Oberbichler D. (2020). Case- Control Comparison of Cervical Spine Radiographs From Horses With a Clinical Diagnosis of Cervical Facet Disease With Normal Horses. Journal of equine veterinary science. 92: 103176.
• Salcedo-Jiménez R, Koenig JB *, Lee OJ, Gibson TWG, Madan P, Koch TG. (2020). Metabolic Activity and Differentiation of Equine Umbilical Cord Blood Mesenchymal Stromal Cells following shockwave therapy. Frontiers in veterinary science. 7: 554306.
• Koenig, J* Sinclair, M Sorge, U. (2019). Comparison of the use of a braided multifilament transfixation suture for field castration with other castration techniques. Equine Veterinary Education. 31(8): 427-431.
• Salcedo R, Gomez DE, Krueger E, Koenig J. (2019). Incarceration of the small intestine through a rent in the ileocecal fold in a horse. The Canadian Veterinary Journal. 60(5): 477-479.
• Beaulieu A, Linden AZ, Phillips J, Arroyo LG, Koenig J, Monteith G. Various 3D printed materials mimic bone ultrasonographically: 3D printed models of the equine cervical articular process joints as a simulator for ultrasound guided intra-articular injections. PLoS One. 2019 Aug 6;14(8)
• Koenig JB*, Silveira A, Cribb NC, Piat P, Laverty S, Sorge US. (2016). Clinical indications, complications, and long-term outcome of esophageal surgeries in 27 horses. The Canadian veterinary journal. 57(12): 1257-1262
• Williams LB, Russell KA, Koenig JB *, Koch TG. (2016). Aspiration, but not injection, decreases cultured equine mesenchymal stromal cell viability. BMC veterinary research. 12: 45.
• Williams LB, Co C, Koenig JB*, Tse C, Lindsay E, Koch TG. (2016). Response to Intravenous Allogneic Equine Cord Blood-Derived Mesenchymal Stromal Cells Administered from Chilled or Frozen State in Serum and Protein-Free Media. Frontiers in veterinary science. 3: 56.
• Williams LB, Koenig JB*, Black B, Gibson TW, Sharif S, Koch TG. (2016). Equine allogeneic umbilical cord blood derived mesenchymal stromal cells reduce synovial fluid nucleated cell count and induce mild self-limiting inflammation when evaluated in an lipopolysaccharide induced synovitis model. Equine veterinary journal. 48(5): 619-25.
• Cribb NC, Koenig J, Sorge U. (2015). Comparison of laparoscopic versus conventional open cryptorchidectomies on intraoperative and postoperative complications and duration of surgery, anesthesia, and hospital stay in horses. Journal of the American Veterinary Medical Association. 246(8): 885-92.
• Bourzac CA, Koenig JB*, Link KA, Nykamp SG, Koch TG. (2014). Evaluation of ultrasmall superparamagnetic iron oxide contrast agent labeling of equine cord blood and bone marrow mesenchymal stromal cells. American journal of veterinary research. 75(11): 1010-7.
• Williams LB, Tessier L, Koenig JB*, Koch TG. (2014). Post-thaw non-cultured and post- thaw cultured equine cord blood mesenchymal stromal cells equally suppress lymphocyte proliferation in vitro. PloS one. 9(12): e113615.
• Link, K., Koenig, JB.*, Silveira, A., Plattner, B. L., & Lillie, B. (2013). Effect of unfocused extracorporeal shock wave therapy on growth factor gene expression in wounds and intact skin of horses. American Journal of Veterinary Research, 74 (2), 324-32
• Elmas, C. R., Koenig, J*., Bienzle, D., Cribb, N. C., Cernicchiaro, N., Cote, N.C., Weese, S.J. (2013). Evaluation of a broad-range real time PCR assay for the diagnosis of septic synovitis in horses. Canadian Journal of Veterinary Research, 77 (3), 211-17.
• Koenig, J.B*., Silveira, A., Chalmers, H., Buenviaje, G., & Lillie, B. N. (2012). Laryngeal neuroendocrine tumor in a horse. Equine Veterinary Education, 24 (1), 12-16.
• Beeler-Marfisi J, Gallastegui Menoyo A, Beck A, König J, Hewson J, Bienzle J: Gelatinous marrow transformation and hematopoietic atrophy in a miniature horse stallion. (Vet Pathology 2011 Mar; 48(2): 451-5)
• Silveira A, Koenig JB*, Arroyo, L, Trout D, Moens N, LaMarre J, Brooks A,: Effect of unfocused extracorporeal shockwave therapy on healing of equine wounds ( Am J Vet Res; 2010; 71(2): 229-234)
• Valverde A, Crawshaw GJ, Cribb N, Bellei M, Gianotti G, Arroyo L, Koenig J, Kummrow M, Costa MC. Anesthetic management of a white rhinoceros (Ceratotherium simum) undergoing an emergency exploratory celiotomy for colic. (Vet Anaesth Analg 2010; 37(3): 280-5)
• Koenig JB*, Silveira A: Use of shockwave in treatment of wounds in horses. Newsletter of the International Veterinary Society for Wound Healing April 2009.
• Koenig JB*, Hart J, Harris D, Cruz A, Bienzle D: Evaluation of endotoxin activity in whole blood measured by neutrophil chemiluminescence in healthy horses and horses with colic (Am J Vet Res 2009: 70 (10):1183-86)
• Koenig JB*, Martin C, Dobson H, Mintchev MP: Use of multi-channel electrogastrography (EGG) for non-invasive assessment of gastric myoelectrical activity in dogs. (Am J Vet Res; 2009; 70: 11-15)
• Koenig JB*, Martin C, Nykamp G, Mintchev MP: Use of multi-channel electrointestinography for non-invasive assessment of large intestinal myoelectrical activity in horses. (Am J Vet Res; 2008; 69 (6))
• Rubio-Martinez LM, Koenig JB*, Halling KB, Wilkins K, Schulz K: Use of a circular external skeletal fixator for stabilization of a comminuted diaphyseal metatarsal fracture in an alpaca (JAVMA; 2007; 230:7:1044-49)
• Koenig JB, Rodriguez A, Colquhoun JK, Staempfli H: Congenital colonic malformation (“short colon”) in a 4-month-old Standardbred foal (Can Vet J; 2007; 48: 416-419).
• Chenier T, Estrada A, Koenig JB*: Theriogenology Question of the Month: diagnosis and treatment of a ruptured vaginal tunique in a thoroughbred stallion (JAVMA; 2007;230: 10: 1469-1472)
• Koenig J, Sawhney S, Cote N, LaMarre J The effect of inflammation on motilin receptors and binding of erythromycin lactobionate in the equine jejunum. (Am J Vet Res; 2006 67: 815-820)
• Koenig J, Cote N: Equine Gastrointestinal Motility. (Can Vet J 2006;47:551–559)
• Koenig J, Cruz A, Genovese R, Fretz P, Trostle S: Rupture of the peroneus tertius tendon in 27 horses (Can Vet J 2005; 46 (6),503-506)
• Koenig J., McDonell WN., Valverde A.: Accuracy of pulse oximetry and capnography in healthy and compromised horses during general anesthesia.(Can J Vet Res 2003; 67(3), 169-174)
• Koenig J, Cote N, Lamarre J, Harris W, Trout D, Kenney D, Monteith G.: Binding of radiolabeled porcine motilin and erythromycin lactobionate to smooth muscle membranes in various segments of the equine gastrointestinal tract (Am J Vet Res 2002; 63 (11), 1545 – 50)
• Koenig JB., Watrous BJ., Kaneps AJ., Adams JG., Parker JE.: Otitis Media in a 7 Month Old Female Llama (JAVMA, 2001, 218(10), 1619-1623)
• Boutros CP, Koenig JB: A combined frontal and maxillary sinus approach for repulsion of the third maxillary molar in a horse. (Can Vet J, 2001, 42 (4), 286-288)
• Koenig J., Hurtig M., Pearce, S., Henderson J., Morris, T.: Ballistic shockwave lithotripsy in an 18 year old Thoroughbred gelding, (Can Vet J, 1999 Mar. 40(3), 185-6.)

Book Chapters 2015-2020

• Koenig, J. (2021). Esophageal Obstruction. Orsini, J Grenager, N de Lahunta, A. Comparative Veterinary Anatomy- A Clinical Approach. 1(1): 1166. Academic Press, United States
• Woods, D Koenig, J. (2020). Synovial Fluid Analysis of the Horse. Sharkey, L Radin, J Seelig, D. Veterinary Cytology. Published, Wiley-Blackwell, United States
• Koenig, J. (2016). Innovative Adjunctive Approaches to Wound Management. Theoret, C Schumacher, J. Equine Wound Management. 3rd(1): 508-511. Published, Wiley, United States

Search PubMed for additional publications by Dr. Koenig.