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W. Glen Pyle

Professor   |   BSc Guelph, PhD Tennessee

Selected Publications

  • Brown SK, Pyle WG, Drozd M, Antonopoulos AS. Cardiovascular Research and social media: connecting with researchers, advancing science. Cardiovasc Res. 2020. 116(14): e215–e217. doi: 10.1093/cvr/cvaa333. 
  • Kane AE, Bisset ES, Keller KM, Ghimire A, Pyle WG, Howlett SE. Age, Sex and Overall Health, Measured As Frailty, Modify Myofilament Proteins in Hearts From Naturally Aging Mice. Sci Rep. 2020. 10(1): 10052. doi: 10.1038/s41598-020-66903-z. 
  • Li X, Zheng S, Tan W, Chen H, Li X, Wu J, Luo T, Ren X, Pyle WG, Wang L, Backx PH, Huang R, Yang FH. Slit2 Protects Hearts Against Ischemia-Reperfusion Injury by Inhibiting Inflammatory Responses and Maintaining Myofilament Contractile Properties. Front Physiol. 2020. 11: 228. doi: 10.3389/fphys.2020.00228. 
  • Ferguson M, Lorenzen-Schmidt I, Pyle WG. Bisphenol S rapidly depresses heart function through estrogen receptor-β and decreases phospholamban phosphorylation in a sex-dependent manner. Sci Rep. 2019. 9(1): 15948. doi: 10.1038/s41598-019-52350-y. 
  • Fernandes RD, Hall A, Ferguson M, Lorenzen-Schmidt I, Balasubramaniam V, Pyle WG. Cardiac changes during the peri-menopausal period in a VCD-induced murine model of ovarian failure. Acta Physiol (Oxf). 2019. 227(1): e13290. doi: 10.1111/apha.13290.  
  • Gatrell LA, Farhat E, Pyle WG, Gillis TE. Contractile function of the excised hagfish heart during anoxia exposure. J Comp Physiol B. 2019. 189(2): 199-211. doi: 10.1007/s00360-019-01208-w.  
  • Ayaz O, Banga S, Heinze-Milne S, Rose RA, Pyle WG, Howlett SE. Long-term testosterone deficiency modifies myofilament and calcium-handling proteins and promotes diastolic dysfunction in the aging mouse heart. Am J Physiol Heart Circ Physiol. 2019. 316(4): H768-H780. doi: 10.1152/ajpheart.00471.2018. 
  • Patel VB, Zhabyeyev P, Chen X, Wang F, Paul M, Fan D, McLean BA, Basu R, Zhang P, Shah S, Dawson JF, Pyle WG, Hazra M, Kassiri Z, Hazra S, Vanhaesebroeck B, McCulloch CA, Oudit GY. PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease. Nat Commun. 2018. 9(1): 5390. doi: 10.1038/s41467-018-07812-8. 
  • Rossi TM, Kavsak PA, Maxie MG, Pearl DL, Pyle WG, Physick-Sheard PW. Post-exercise cardiac troponin I release and clearance in normal Standardbred racehorses. Equine Vet J. 2019. 51(1): 97-101. doi: 10.1111/evj.12486_62. 
  • Feridooni HA, MacDonald JK, Ghimire A, Pyle WG, Howlett SE. Acute exposure to progesterone attenuates cardiac contraction by modifying myofilament calcium sensitivity in the female mouse heart. Am J Physiol Heart Circ Physiol. 2017. 312(1): H46-H59. doi: 10.1152/ajpheart.00073.2016. 
  • Cheng Y, Hogarth KA, O'Sullivan ML, Regnier M, Pyle WG. 2-Deoxyadenosine triphosphate restores the contractile function of cardiac myofibril from adult dogs with naturally occurring dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2016. 310(1): H80-91. doi: 10.1152/ajpheart.00530.2015.