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W. Glen Pyle

Professor   |   BSc Guelph, PhD Tennessee

Current Graduate Students

Selected Publications

  • Acute exposure to progesterone attenuates cardiac contraction by modifying myofilament calcium sensitivity in the female mouse heart.  Feridooni HA, MacDonald JK, Ghimire A, Pyle WG, Howlett SE.
    Am J Physiol Heart Circ Physiol. 2016 Oct 28:ajpheart.00073.2016. doi: 10.1152/ajpheart.00073.2016. [Epub ahead of print]  PMID: 27793852 [PubMed - as supplied by publisher]
  • Similar articles2.Day-Night Dependence of Gene Expression and Inflammatory Responses in the Remodeling Murine Heart post-Myocardial Infarction.  Bennardo M, Alibhai FJ, Tsimakouridze EV, Chinnappareddy N, Podobed P, Reitz CJ, Pyle WG, Simpson JA, Martino TA.  Am J Physiol Regul Integr Comp Physiol. 2016 Oct 12:ajpregu.00200.2016. doi: 10.1152/ajpregu.00200.2016. [Epub ahead of print]  PMID: 27733386 [PubMed - as supplied by publisher]
  • The neglected messengers: Control of cardiac myofilaments by protein phosphatases.  Lorenzen-Schmidt I, Clarke SB, Pyle WG.  J Mol Cell Cardiol. 2016 Dec;101:81-89. doi: 10.1016/j.yjmcc.2016.10.002.  PMID: 27721025
  • 2-Deoxyadenosine triphosphate restores the contractile function of cardiac myofibril from adult dogs with naturally occurring dilated cardiomyopathy.  Cheng Y, Hogarth KA, O'Sullivan ML, Regnier M, Pyle WG.  Am J Physiol Heart Circ Physiol. 2016 Jan 1;310(1):H80-91. doi: 10.1152/ajpheart.00530.2015.  PMID: 26497964 [PubMed - indexed for MEDLINE]
  • Consequences of Circadian and Sleep Disturbances for the Cardiovascular System.  Alibhai FJ, Tsimakouridze EV, Reitz CJ, Pyle WG, Martino TA.  Can J Cardiol. 2015 Jul;31(7):860-72. doi: 10.1016/j.cjca.2015.01.015. Review.  PMID: 26031297 [PubMed - indexed for MEDLINE]
  • Cold acclimation increases cardiac myofilament function and ventricular pressure generation in trout.  Klaiman JM, Pyle WG, Gillis TE.  J Exp Biol. 2014 Dec 1;217(Pt 23):4132-40. doi: 10.1242/jeb.109041.  PMID: 25278471 [PubMed - indexed for MEDLINE]
  • The day/night proteome in the murine heart.  Podobed P, Pyle WG, Ackloo S, Alibhai FJ, Tsimakouridze EV, Ratcliffe WF, Mackay A, Simpson J, Wright DC, Kirby GM, Young ME, Martino TA.
    Am J Physiol Regul Integr Comp Physiol. 2014 Jul 15;307(2):R121-37.  PMID: 24789993 [PubMed - indexed for MEDLINE]
  • Short-term disruption of diurnal rhythms after murine myocardial infarction adversely affects long-term myocardial structure and function.  Alibhai FJ, Tsimakouridze EV, Chinnappareddy N, Wright DC, Billia F, O'Sullivan ML, Pyle WG, Sole MJ, Martino TA.  Circ Res. 2014 May 23;114(11):1713-22. doi: 10.1161/CIRCRESAHA.114.302995.  PMID: 24687134 [PubMed - indexed for MEDLINE]
  • Cardiac contraction, calcium transients, and myofilament calcium sensitivity fluctuate with the estrous cycle in young adult female mice.  MacDonald JK, Pyle WG, Reitz CJ, Howlett SE.
    Am J Physiol Heart Circ Physiol. 2014 Apr 1;306(7):H938-53. doi: 10.1152/ajpheart.00730.2013.  PMID: 24464757 [PubMed - indexed for MEDLINE].
  • The impact of ovariectomy on calcium homeostasis and myofilament calcium sensitivity in the aging mouse heart.  Fares E, Pyle WG, Ray G, Rose RA, Denovan-Wright EM, Chen RP, Howlett SE.
  • PLoS One. 2013 Sep 18;8(9):e74719. doi: 10.1371/journal.pone.0074719.  PMID: 24058623 [PubMed - indexed for MEDLINE]
  • Shaw EE, Wood P, Kulpa J, Yang FH, Summerlee AJ, Pyle WG. Relaxin alters cardiac myofilament function through a PKC-dependent pathway. Am J Physiol Heart Circ Physiol. 2009 May 8. [Epub ahead of print].
  • Yang F, Aiello DL, Pyle WG. Cardiac myofilament regulation by protein phosphatase type 1alpha and CapZ. Biochem Cell Biol 2008 Feb;86(1):70-8.
  • Pyle WG, Solaro RJ. At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function. Circ Res 2004; 94: 296-305.
  • Pyle WG. Searching for the missing link: a role for the actin capping protein in heart failure. Can J Cardiol 2004; 20: 1429-32.
  • Pyle WG, Hart MC, Cooper JA, Sumandea MP, De Tombe PP, Solaro RJ. Actin capping protein: an essential element in protein kinase signaling to the myofilaments. Circ. Res. 2002; 90: 1299-1306.
  • Pyle WG, Sumandea MP, Solaro RJ, De Tombe PP. Troponin I serines 43/45 and regulation of cardiac myofilament function. Am. J. Physiol. Heart Circ. Physiol. 2002; 283: H1215-H1224.