• Office
  • Biomed 3645
  • 54922
  • Lab:
  • OVC 3649
  • 54685

Brenda L. Coomber

Professor   |   BSc, MSc Guelph, PhD Toronto

Research Interests

  • Angiogenesis and Anti-angiogenic Therapy in Cancer
  • Tumour Microenvironment & Metabolism
  • Companion Animal Cancer Biology

Selected Publications

Thompson JJ, Morrison JA, Pearl DL, Boston SE, Wood GA, Foster RA, Coomber BL. Receptor tyrosine kinase expression profiles in canine cutaneous mast cell tumors. Vet Pathol. 2016, 53(3):545-58.

Farias N, Ho N, Butler S, Delaney L, Morrison J, Shahrzad S, Coomber BL. The effects of folic acid on global DNA methylation and colonosphere formation in colon cancer cell lines. J Nutr Biochem. 2015, 26(8):818-26. 

Ho N, Coomber BL. Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells. Exp Cell Res. 2015, 331(1):73-81.

Skowronski K, Andrews J, Rodenhiser DI, Coomber BL. Genome-wide analysis in human colorectal cancer cells reveals ischemia-mediated expression of motility genes via DNA hypomethylation. PLoS One. 2014, 9(7):e103243.

Adamcic U, Skowronski K, Peters C, Morrison J, Coomber BL. The effect of bevacizumab on human malignant melanoma cells with functional VEGF/VEGFR2 autocrine and intracrine signaling loops. Neoplasia. 2012, 14(7):612-23.

Kuczynski EA, Viloria-Petit AM, Coomber BL. Colorectal carcinoma cell production of transforming growth factor beta decreases expression of endothelial cell vascular endothelial growth factor receptor 2. Cancer. 2011, 117(24):5601-11.

Thompson JJ, Yager JA, Best SJ, Pearl DL, Coomber BL, Torres RN, Kiupel M, Foster RA. Canine subcutaneous mast cell tumors: cellular proliferation and KIT expression as prognostic indices. Vet Pathol. 2011, 48(1):169-81.