Dr. Byram Bridle
  • Office
  • PAHL 4834
  • 54657
  • Lab:
  • PAHL 3808
  • 53616

Areas of Interest

  • cancer immunotherapy
  • oncolytic virotherapy
  • role of type I interferon signaling in regulating cytokine responses

   

 Dr. Bridle is a viral immunologist whose research program has two arms. One is to develop novel, highly targeted biotherapies for the treatment of cancers. In an effort to kill malignant cells with minimal bystander damage to normal tissues, two approaches are combined: 1. cancer immunotherapy that directs the power of a patient’s immune system against their own tumour(s) and, 2. oncolytic virotherapy, which utilizes viruses that replicate in and kill only cancerous cells. The exquisite specificity, systemic targeting capability and short treatment windows of these therapies hold promise that cancer patients might be effectively treated with reduced side effects and at minimal cost. The goal is to translate the most promising iterations of these therapies into clinical trials in companion animals as a stepping stone towards testing in human patients. A second emphasis of the lab is the study of host responses to viruses. Specifically, efforts are being invested into understanding the mechanisms underlying virus-induced cytokine storms. We have identified a critical role of signaling through the type I interferon receptor in the negative regulation of an extensive network of cytokines.

     This lab seeks researchers who are collaborative, highly motivated, innovative, hard-working and want to have a significant impact in the field of viral immunology. An outstanding academic record, excellent writing and oral presentation skills and a collaborative approach are essential. Trainees will have an opportunity to gain valuable, hands-on research experience in a variety of areas. Learning the fundamental principles of immunology, cancer biology and virology is an emphasis. Applicants who are willing to work longer hours than average, are passionate about pursuing a career in research, are excellent communicators, punctual, autonomous and possess excellent technical skills will excel in this laboratory. In return, members can expect diligent mentorship, access to state-of-the-art research resources, with opportunities spanning the basic to translational research spectrum, giving them the resources needed to potentially publish in the highest impact scientific journals and placing the future of their research career in their own hands.

Research Funding:

The Bridle lab is currently funded by:

  • The Natural Sciences and Engineering Research Council of Canada (NSERC)
  • The Terry Fox Research Institute
  • National Centre of Excellence in Biotherapeutics for Cancer Treatment (BioCanRx)
  • The Pet Trust Foundation
  • The Smiling Blue Skies Cancer Fund
  • Canadian Foundation for Innovation - John R. Evans Leaders Fund
  • Ministry of Research and Innovation Ontario Research Fund - Research Infrastructure Program

The Bridle lab is part of the…

  • Canadian Oncolytic Virus Consortium
  • Canadian Society of Immunology

 

Lab Profile

The Bridle lab is currently funded by:

As Principal Investigator…

  • The Natural Sciences and Engineering Research Council of Canada (NSERC)
  • The Terry Fox Research Institute
  • Cancer Research Society
  • The Pet Trust Foundation
  • The Smiling Blue Skies Cancer Fund (via The Pet Trust Fund)
  • Canadian Foundation for Innovation - John R. Evans Leaders Fund
  • Ministry of Research and Innovation Ontario Research Fund - Research Infrastructure Program
  • NSERC Research Tools and Infrastructure

As a Co-Investigator…

  • National Centre of Excellence in Biotherapeutics for Cancer Treatment (BioCanRx)
  • Canadian Breast Cancer Foundation

Dr. Bridle is a member of the…

  • Canadian Oncolytic Virus Consortium
  • Canadian Society of Immunology

Graduate Students

• Allison, Katrina (MSc program)
• AuYeung, Wing Ka “Amanda” (MSc program)
• Mould, Robert (PhD program)
• Singh, Mankerat (Undergraduate research project)
• van Vloten, Jacob (PhD program)
• Whaley, Megan (PhD program)

Former Students:

  • De Carvalho Nakamura, Julia (Summer Research Assistant)
  • de Jong, Jondavid (Postdoctoral Fellow)
  • Desai, Manali (Summer Research Assistant)
  • Geronimo, Katrina (Secondary School; Sanofi Biogenius Canada science competition)
  • Hattin, Larissa (Undergraduate research project; Summer Research Assistant)
  • Kim, Julia (Summer Research Assistant x 2)
  • Kodeeswaran, Arthane (Secondary School; Sanofi Biogenius Canada science competition)
  • Lusty, Evan (Undergraduate Research Project; Summer Research Assistant x 2)
  • Morgenstern, Jason (Summer Research Assistant x 2; Work-Study program)
  • Oke, Sofia (Undergraduate Research Project)
  • Rasiuk, Alexandra (Undergraduate Research Project; MSc program)
  • Saturno, Julia (Summer Research Assistant)
  • Spangler-Forgione, Haley (Summer Research Assistant)
  • Syed, Zafir (MSc program)
  • Talan, Micaella (Secondary School; Sanofi Biogenius Canada science competition)
  • Tin, Brittney (Secondary School; Sanofi Biogenius Canada science competition)
  • Ternamian, Christian (MSc program)
  • Walsh, Scott (Postdoctoral Fellow)

Research and Professional Staff

Clark, Mary Ellen Clark      (lab management, testing efficacy of oncolytic viruses under various environmental conditions)

McBey, Betty-Anne               (flow cytometry, propagation of viruses)

Deng, Li (Postdoctoral Fellow)

Karimi, Khalil (Research Associate)

Teaching

VETM*3080               Veterinary Physiology and Biochemistry (Head Instructor: Veterinary Immunology)

VETM*3450               Principles of Disease in Veterinary Medicine (Immunology Review Lecture)

BIOM*4150/6702      Cancer Biology (Tumour Immunology Unit)

BIOM*6800               Gene Expression in Health and Disease (Lecture: “Identification of genes encoding tumour-associated antigens and their use in cancer vaccine design”)

PABI*6104                 Mechanisms of Disease (Lecture: “Oncolytic and Immunotherapies”)

Selected Publications

Search PubMed for additional publications by Dr. Bridle.