Andrew S. Peregrine

Associate Professor | Pathobiology | BVMS, PhD, DVM, Diplomate EVPC, Diplomate ACVM (Veterinary Parasitology)

  • Office
  • PAHL 3825
  • 54714
  • Lab:
  • PAHL 3808
  • 53616

Areas of Interest

Epidemiology and impact of parasitic infections. Development of parasite control programs that minimize the rate of development of drug resistance.

Research projects are currently being carried out with the following objectives:

  • Determine the efficacy of closantel against ivermectin- and fenbendazole-resistant Haemonchus contortus infections in sheep;
  • Evaluate the effect of targeted selective treatment at lambing on Haemonchus burdens on Ontario sheep farms with anthelmintic resistance.
  • Determine if drug-resistant strains of Dirofilaria immitis (heartworm) are present in Ontario dogs;
  • Identify risk factors for the occurrence of drug-resistant genotypes of Dirofilaria immitis;
  • Determine the prevalence of Echinococcus multilocularis in wild canids in southern Ontario;
  • Identify high risk areas or “hot spots” for Echinococcus multilocularis infection in southern Ontario.

Graduate Students

Jonathon Kotwa
MSc student (F’15; advisor)

Emma Borkowski
PhD student (F’15; advisor)

Christine James
MSc student (F’14; co-advisor)

Jordan Minigan
MSc student (F’14; co-advisor)

Trisha Westers
PhD Student (W'13; advisor)

Former Students:

Dylan Engell BSc (Guelph). MBS – GRADUATED S’15
Genotype analysis to evaluate the occurrence of macrocyclic lactone resistance in Dirofilaria immitis (heartworm) infecting dogs in Ontario

Laura Falzon DVM (Perugia, Italy). PhD – GRADUATED F’12
Gastrointestinal nematodes in Ontario sheep flocks: an epidemiological study of overwintering and anthelmintic resistance

Ansarah Hosein DVM (Trinidad). MSc – GRADUATED S’12
Evaluation of the prevalence and impact of Tritrichomonas foetus in cats

Bradley De Wolf BSc (Waterloo). MSc – GRADUATED S’12
Cysticercus ovis in Canadian sheep: risk factors and a simulation model to assess control measures

Teaching

DVM program:

  • VETM*3080 – Veterinary Physiology
  • VETM*3410 - Health Management II
  • VETM*4460 - Food Animal Medicine and Surgery
  • VETM*4470 – Medicine and Surgery – Dog and Cat
  • VETM*4420 - Clinical Pharmacology
  • VETM*4530 - Advanced Health Management for Companion Animals
  • VETM*4530 - Advanced Health Management for Horses
  • VETM*4530 - Advanced Health Management for Small Ruminants
  • Phase 4 - Veterinary Diagnostic Pathology
  • Phase 4 - Equine Health Elective
  • Phase 4 - Small Ruminant Elective
  • Phase 4 - Equine Primary Care Elective

Other teaching:

  • POPM*4040 - Epidemiology of food-borne diseases
  • BIOM*4090 - Pharmacology
  • POPM*6300 - Epidemiology of zoonoses

Selected Publications

 

  • Bouchard, C., Leonard, E., Koffi, J.K., Pelcat, Y., Peregrine, A., Chilton, N., Rochon, K., Lysyk, T., Lindsay, L.R., Ogden, N.H. (2015) The increasing risk of Lyme disease in Canada. Canadian Veterinary Journal 56, 693-699.
  • Bourguinat, C., Lee, A.C.Y., Lizundia, R., Blagburn, B.L., Liotta, J.L., Kraus, M.S., Keller, K., Epe, C., Letourneau, L., Kleinman, C.L., Paterson, T., Gomez, E.C., Montoya-Alonso, J.A., Smith, H., Bhan, A., Peregrine, A.S., Carmichael, J., Drake, J., Schenker, R., Kaminsky, R., Bowman, D.D., Geary, T.G., Prichard, R.K. (2015) Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance.  Veterinary Parasitology 210, 167-178.
  • Falzon, L.C., van Leeuwen, J., Menzies, P.I., Jones-Bitton, A., Sears, W., Jansen, J.T., Peregrine, A.S. (2015) Erratum to: Comparison of calculation methods used for the determination of anthelmintic resistance in sheep in a temperate continental climate. Parasitology Research 114, 1631-1643.
  • Oscos-Snowball, A., Tan, E., Peregrine, A.S., Foster, R., Bronsoiler, J., Gottstein, B., Jenkins, E., Gesy, K., Bienzle, D. (2015) What is your diagnosis? Fluid aspirated from an abdominal mass in a dog. Veterinary Clinical Pathology 44, 167-168.
  • Falzon, L.C., O’Neill, T.J., Menzies, P.I., Peregrine, A.S., Jones-Bitton, A., vanLeeuwen, J., Mederos, A. (2014) A systematic review and meta-analysis of factors associated with anthelmintic resistance in sheep. Preventive Veterinary Medicine 117, 388-402.
  • Mederos, A., Kelton, D., Peregrine, A.S., VanLeeuwen, J., Fernández, S., LeBoeuf, A., Menzies, P. and Martin, R. (2014) Evaluation of the utility of subjective clinical parameters for estimating fecal egg counts and packed cell volume in Canadian sheep flocks. Veterinary Parasitology 205, 568-574.
  • Jardine, C.M., Pearl, D.L., Puskas, K., Campbell, D.G., Shirose, L., Peregrine, A.S. (2014) The impact of land use, season, age, and sex on the prevalence and intensity of Baylisascaris procyonis infections in raccoons (Procyon lotor) from Ontario, Canada. Journal of Wildlife Diseases 50, 784-791.
  • Peregrine, A.S., Nykamp, S.G., Carey, H., Kruth, S. (2014) Paragonimosis in a cat and the temporal progression of pulmonary radiographic lesions following treatment. Journal of the American Animal Hospital Association 50, 356-360.
  • Falzon, L.C., Menzies, P.I., VanLeeuwen, J., Shakya, K.P., Jones-Bitton, A., Avula, J., Jansen, J.T., Peregrine, A.S. (2014) Pilot project to investigate over-wintering of free-living gastrointestinal nematode larvae of sheep in Ontario, Canada. Canadian Veterinary Journal 55, 749-756.
  • Stull, J.W., Brophy, J., Sargeant, J.M., Peregrine, A.S., Lawson, M.L., Ramphal, R., Samson, L., Bowes, J., Weese, J.S. (2014) Knowledge, attitudes, and practices related to pet contact by immunocompromised children with cancer and immunocompetent children with diabetes. Journal of Paediatrics 165, 348-355.
  • Skelding, A., Brooks, A., Stalker, M., Mercer, N., de Villa, E., Gottstein, B., Peregrine, A.S. (2014) Hepatic alveolar hydatid disease (Echinococcus multilocularis) in a boxer dog from southern Ontario. Canadian Veterinary Journal 55, 551-553.
  • Falzon, L.C., van Leeuwen, J., Menzies, P.I., Jones-Bitton, A., Sears, W., Jansen, J.T., Peregrine, A.S. (2014) Comparison of calculation methods used for the determination of anthelmintic resistance in sheep in a temperate continental climate. Parasitology Research 113, 2311-2322.
  • Procter, T.D., Pearl, D.L., Finley, R.L., Leonard, E.K., Janecko, N., Reid-Smith, R.J., Weese, J.S., Peregrine, A.S., Sargeant, J.M. (2014) A cross-sectional study examining the prevalence and risk factors for anti-microbial-resistant generic Escherichia coli in domestic dogs that frequent dog parks in three cities in south-western Ontario, Canada. Zoonoses and Public Health 61, 250-259.
  • Procter, T.D., Pearl, D.L., Finley, R.L., Leonard, E.K., Janecko, N., Reid-Smith, R.J., Weese, J.S., Peregrine, A.S., Sargeant, J.M. (2014) A cross-sectional study examining Campylobacter and other zoonotic enteric pathogens in dogs that frequent dog parks in three cities in south-western Ontario and risk factors for shedding of Campylobacter spp. Zoonoses and Public Health 61, 208-218.
  • Karrow, N.A., Goliboski, K., Stonos, N., Schenkel, F., Peregrine, A. (2014) Review: Genetics of helminth resistance in sheep. Canadian Journal of Animal Science 94, 1-9.
  • Peregrine, A.S., Molento, M.B., Kaplan, R.M., Nielsen, M.K. (2014) Anthelmintic resistance in important parasites of horses: Does it really matter? Veterinary Parasitology 201, 1-8.
  • Falzon, L.C., Menzies, P.I., Vanleeuwen, J., Jones-Bitton, A., Shakya, K.P., Avula, J., Jansen, J.T., Peregrine, A.S. (2014) Efficacy of targeted anthelmintic treatment for suppression of the peri-parturient egg rise in ewes and impact on 50-day lamb weights. Small Ruminant Research 116, 206-218.
  • Falzon, L.C., Menzies, P.I., Vanleeuwen, J., Jones-Bitton, A., Shakya, K.P., Avula, J., Jansen, J.T., Peregrine, A.S. (2013) A survey of farm management practices and their associations with anthelmintic resistance in sheep flocks in Ontario, Canada. Small Ruminant Research 114, 41-45.
  • DeWolf, B.D., Peregrine, A.S., Jones-Bitton, A., Jansen, J.T., Menzies, P.I. (2014) Taenia ovis infection and its control: a Canadian perspective. New Zealand Veterinary Journal 62, 1-7.
  • Barrere, V., Falzon, L.C., Shakya, K.P., Menzies, P.I., Peregrine, A.S., Prichard, R.K. (2013) Assessment of benzimidazole resistance in Haemonchus contortus in sheep flocks in Ontario, Canada: Comparison of detection methods for drug resistance. Veterinary Parasitology 198, 159-165.
  • DeWolf, B.D., Poljak, Z., Peregrine, A.S., Jones-Bitton, A., Jansen, J.T., Menzies, P.I. (2103) Development of a Taenia ovis transmission model and an assessment of control strategies. Veterinary Parasitology 198, 127-135.
  • Hosein, A., Kruth, S.A., Pearl, D.L., Richardson, D., Maggs, J.C., Peach, H.A., Peregrine, A.S. (2013) Isolation of Tritrichomonas foetus from cats sampled at a cat clinic, cat shows and a humane society in southern Ontario. Journal of Feline Medicine and Surgery 15, 706-711.
  • Stull, J.W., Peregrine, A.S., Sargeant, J.M., Weese, J.S. (2013) Pet husbandry and infection control practices related to zoonotic disease risks in Ontario, Canada. BMC Public Health. 13:520 doi:10.1186/1471-2458-13-520.
  • Falzon, L.C., Menzies, P.I., Shakya, K.P., Jones-Bitton, A., Vanleeuwen, J., Avula, J., Jansen, J.T., Peregrine, A.S. (2013) A longitudinal study on the effect of lambing season on the periparturient egg rise in Ontario sheep flocks. Preventive Veterinary Medicine 110, 467-480.
  • Falzon, L.C., Menzies, P.I., Shakya, K.P., Jones-Bitton, A., Vanleeuwen, J., Avula, J., Stewart, H., Jansen, J.T., Taylor, M.A., Learmount, J., Peregrine, A.S. (2013) Anthelmintic resistance in sheep flocks in Ontario, Canada. Veterinary Parasitology 193, 150-162.
  • Pufall, E.L., Jones-Bitton, A., McEwen, S.A., Brown, T.M., Edge, V.L., Rokicki, J., Karpiej, K., Peregrine, A.S., Simard, M. (2012) Prevalence of zoonotic anisakid nematodes in Inuit-harvested fish and mammals from the Eastern Canadian Arctic. Foodborne Pathogens and Disease 9, 1002-1009.
  • DeWolf, B.D., Peregrine, A.S., Jones-Bitton, A., Jansen, J.T., MacTavish, J., Menzies, P.I. (2012) Distribution of, and risk factors associated with, sheep carcass condemnations due to Cysticercus ovis infection on Canadian sheep farms. Veterinary Parasitology 190, 434-441.
  • James, F.M.K., da Costa, R.C., Fauber, A., Peregrine, A.S., McEwen, B., Parent, J.M. and Bergman, R. (2012) Clinical and MRI findings in three dogs with polycystic meningiomas. Journal of the American Animal Hospital Association 48, 331-338.
  • Peregrine, A.S., Jenkins, E.J., Barnes, B., Johnson, S., Polley, L., Barker, I.K., De Wolf, B. and Gottstein, B. (2012) Alveolar hydatid disease (Echinococcus multilocularis) in the liver of a Canadian dog in British Columbia, a newly endemic region. Canadian Veterinary Journal 53, 870-874.
  • Stull, J.W., Peregrine, A.S., Sargeant, J.M., Weese, J.S. (2012) Household knowledge, attitudes and practices related to pet contact and associated zoonoses in Ontario, Canada. BMC Public Health 12, 553, doi: 10.1186/1471-2458-12-553.
  • Jenkins, E.J., Peregrine, A.S., Hill, J.E., Somers, C., Gesy, K., Barnes, B., Gottstein, B., Polley, L. (2012) Detection of European strain of Echinococcus multilocularis in North America. Emerging Infectious Diseases 18, 1010-1012.
  • Mederos, A., Waddell, L., Sánchez, J., Kelton, D., Peregrine, A.S., Menzies, P., VanLeeuwen, J. and Rajić, A. (2012) A systematic review-meta-analysis of primary research investigating the effect of selected alternative treatments on gastrointestinal nematodes in sheep under field conditions. Preventive Veterinary Medicine 104, 1-14.
  • Leonard, E.K., Pearl, D.L., Finley, R.L., Janecko, N., Reid-Smith, R.J., Peregrine, A.S. and Weese, J.S. (2012) Comparison of antimicrobial resistance patterns of Salmonella spp. and Escherichia coli recovered from pet dogs from volunteer households in Ontario (2005-06). Journal of Antimicrobial Chemotherapy 67, 174-181.
  • McDowall, R.M., Peregrine, A.S., Leonard, E.K., Lacombe, C., Lake, M., Rebelo, A.R. and Cai, H.Y. (2011) Evaluation of the zoonotic potential of Giardia duodenalis in fecal samples from dogs and cats in Ontario. Canadian Veterinary Journal 52, 1329-1333.
  • Pufall, E.L., Jones, A.Q., McEwen, S.A., Lyall, C., Peregrine, A.S. and Edge, V.L. (2011) Community-derived research dissemination strategies in an Inuit community. International Journal of Circumpolar Health 70, 532-541.
  • Bourguinat, C., Keller, K., Bhan, A., Peregrine, A., Geary, T., Prichard, R. (2011) Macrocyclic lactone resistance in Dirofilaria immitis. Veterinary Parasitology 181, 388-392.
  • Pufall, E.L., Jones, A.Q., McEwen, S.A., Lyall, C., Peregrine, A.S., Edge, V.L. (2011) Perception of the importance of traditional country foods to the physical, mental, and spiritual health of Labrador Inuit. The Arctic Journal 64, 242-250.
  • Leonard, E.K., Pearl, D.L., Janecko, N., Weese, J.S., Reid-Smith, R.J., Peregrine, A.S. and Finley, R.L. (2011) Factors related to Campylobacter spp. carriage in client-owned dogs visiting veterinary clinics in a region of Ontario, Canada. Epidemiology and Infection 139, 1531-1541.
  • Trotz-Williams, L.A., Jarvie, B.D., Peregrine, A.S., Duffield, T.F. and Leslie, K.E. (2011) Efficacy of halofuginone lactate in the prevention of cryptosporidiosis in dairy calves. The Veterinary Record 168, 509, doi: 10.1136/vr.d1492.
  • Aliaga-Leyton, A., Friendship, R., Dewey, C.E., Todd, C. and Peregrine, A.S. (2011) Isospora suis infection and its association with postweaning performance on three southwestern Ontario swine farms. Journal of Swine Health and Production 19, 94-99.
  • Leonard, E.K., Pearl, D.L., Finley, R.L., Janecko, N., Peregrine, A.S., Reid-Smith, R.J. and Weese, J.S. (2011) Evaluation of pet-related management factors and the risk of Salmonella spp. carriage in pet dogs from volunteer households in Ontario (2005-2006). Zoonoses and Public Health 58, 140-149.
  • Aliaga-Leyton, A., Webster, E., Friendship, R., Dewey, C., Vilaça, K. and Peregrine A.S. (2011) An observational study on the prevalence and impact of Isospora suis in suckling piglets in southwestern Ontario, and risk factors for shedding oocysts. Canadian Veterinary Journal 52, 184-188.
  • Guthrie, A.D., Learmount, J., VanLeeuwen, J., Peregrine, A.S., Kelton, D., Menzies, P.I., Fernández, S., Martin, R.C., Mederos, A. and Taylor, M.A. (2010) Evaluation of a British computer model to simulate gastrointestinal nematodes in sheep on Canadian farms. Veterinary Parasitology 174, 92-105.
  • Mederos, A., Fernández, S., VanLeeuwen, J., Peregrine, A.S., Kelton, D., Menzies, P., LeBoeuf, A. and Martin, R. (2010) Prevalence and distribution of gastrointestinal nematodes on 32 organic and conventional commercial sheep farms in Ontario and Quebec, Canada (2006 – 2008). Veterinary Parasitology 170, 244-252.

Search PubMed for additional publications by Dr. Peregrine.