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Effect of Lymphoma on the Blood Test for Kidney Disease SDMA

Background:

One role of the kidneys is to remove some body wastes. When kidneys are weak, the concentrations of some body wastes will go up in the blood. These wastes include urea, creatinine, and phosphorus. Recently, the concentration of another waste product, SDMA, has been shown to be more sensitive than the others for the diagnosis of kidney disease. It is also possible that SDMA is a waste product of lymphoma cancer cells. If lymphoma cells make SDMA, then it is possible this test should not be used to diagnose kidney disease in these dogs. It is also possible that SDMA could be used to help judge how well anticancer treatment is working, by seeing if the concentration of SDMA in the blood goes down.

The goal of this study is to determine if dogs with lymphoma have increased values of SDMA. This will be determined my measuring SDMA level in your dog before, during, and after chemotherapy. Urea, creatinine and phosphorus will also be measured, as well as a urine sample will be examined, to help determine if your dog has kidney disease. The blood sample will also be tested for uric acid, which can be elevated when lymphoma cells are destroyed.

Inclusion criteria:

  • Dogs of any breed or age
  • A clinical diagnosis of multicentric (B/T-cell) lymphoma
  • Scheduled for treatment at OVC or other participating hospitals

Samples required:

  • Blood sample (3mL) at every scheduled visit
  • Recommended:
    • urine sample at initial visit
    • Abdominal ultrasound at initial visit & specific time points

Incentives:

  • Abdominal ultrasound(s) examination(s) (if not already performed)
  • Bloodwork: biochemistry profile (if not already performed)

Researcher:

Dr. Tony Abrams-Ogg (PI)

Contact:

Vicky Sabine (PhD), Clinical Research Coordinator

Funded by OVC Pet Trust and a gift from a private donor.